Matrixyl Synthe-6 Booster

Anti-Aging Peptide & topical wrinkle filler Palmitoyl Tetrapeptide-38

Matrixyl® Synthe'6® or Palmitoyl Tetrapeptide 38 is an amazing new peptide for your favorite serum or moisturizer! As a result, your skin will look smoother, visibly less wrinkled, and youthful!

€29,95
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Matrixyl Synthe-6 Serum Booster is a concentrated 0.5 oz (approximately 300 drops) peptide booster containing Palmitoyl Tetrapeptide-38 formulated to help fill and smooth expression lines on the forehead and at the eye corners when used at a recommended 2% concentration.

Suppose you struggle with crow's feet or horizontal forehead lines and find department-store products are too diluted. In that case, this booster is designed to give you measurable peptide strength you can add to your current serums or moisturizers. Use it to customize clinical-strength results without unnecessary fillers.

  • Recommended 2% use rate for DIY blending into serums or creams
  • 0.5 oz bottle equals roughly 300 drops, enough to make 16+ one-ounce batches
  • Contains Palmitoyl Tetrapeptide-38 (Matrixyl Synthe-6), a peptide targeted for wrinkle filling
  • Paraben-free formulation with no added fillers or preservatives listed
  • Blue glass dropper bottle for light protection; refrigerate after opening to extend stability

Unlike many pre-made lotions that include minimal peptide concentrations and filler ingredients, this booster lets you control concentration and pairing. Add it to humectant-rich serums, hyaluronic acid bases, or lightweight moisturizers for targeted lifting and smoothing effects.

Packaged in a blue glass dropper bottle with clear usage guidance and recommended for ingredient-savvy users seeking measurable peptide concentrations. Follow the 2% guideline and storage instructions for best results.

Targets:

Matrixyl Synthe-6 is a powerful serum booster. It benefits your skin in numerous ways, improving its appearance and giving you a more youthful and radiant look. It specifically targets:

  • Anti-aging
  • Anti-wrinkle
  • Firms and lifts
  • Crow's feet
  • Expression lines
  • Collagen promotion
  • Cellular regeneration

Adding Matrixyl Synthe-6 to your favorite serum or lotion can give you the lifting, firming, and rejuvenating results you've been longing for. Including it in your own DIY skincare products can give you the personalized age-defying effects you need for your skin type and needs.

EWG Score

The Skin Deep® ingredient hazard score, from 1 to 10, reflects known and suspected hazards linked to the ingredients. Learn more →
1-2 Low Hazard
3-6 Moderate Hazard
7-10 High Hazard

  • Hydroxypropyl cyclodextrin Origin:
  • palmitoyl tripeptide-38 Origin:
  • Glycerin Origin:
  • Water Origin:

Why should I add Matrixyl Synthe 6 to my routine?
Matrixyl Synthe 6 provides essential components that cells need to function as they did when the skin was young. As a result, a more beautiful, youthful look appears. It also provides beneficial nutrients and is safe to use on the skin. In addition, clinical studies have shown that it promotes healthy-looking complexions without irritation—good news for those with sensitive skin.
What does this product target?
Matrixyl targets some of the women's most problematic areas, including sagging, droopy skin, wrinkles around the eyes, nose, mouth, and forehead, and common ailments for mature skin with quick results!
Does this product need to be refrigerated?
We recommend placing Matrixyl Synthe 6 in your fridge to keep it fresh for the next time you need it.

INCI: Glycerin, Water, Hydroxypropyl Cyclodextrin, Palmitoyl Tripeptide-38

Recommended Usage Rate: 2%

Place in the refrigerator upon arrival.

Color: Colorless to pale yellow

Appearance: Clear liquid

Solubility: Water soluble

pH: Not available

Scent: No added fragrance, unscented

Storage: Store in a cool, dry place

Shelf-life: 12 months after opening

Country of Origin: France

Raw Material: Plant-based

Animal Testing: Cruelty-free

GMO: Non-GMO

Vegan: Yes

CAS: 128446-35-5/1447824-23-8

HS Code: 3504.00

Palmitoyl tripeptide-38 is a wrinkle-filler obtained from a tripeptide in collagen VI. It smooths fine lines from the inside out by adding support to the dermis.

For a 2% concentration of Matrixyl Synthe-6 in a 1-ounce skincare product, bulk base, or formula, add 18 drops.

For a 2% concentration of Matrixyl Synthe-6 in a 2-ounce skincare product, bulk base, or formula, add 36 drops.

Matrixyl®-Synthe'6® is a smoothing peptide used for lotion making. It is not intended to be applied directly to the skin.

Make a quick product using a base of Hyaluronic Acid, serum, or moisturizer.

Applications:

  • Anti-Aging Face Creams
  • Anti-Aging Serums
  • Day and Night Moisturizers
  • Firming Body Lotions
  • Highly Concentrated Back Bar Facial Treatments
  • Hyaluronic Facial Serums and Gels
  • Make-up Including Foundation
  • Tightening Eye Creams, Eyelash, Eyebrow Formulas, and more!

MSDS Sheet

Sederma

850061380388

Do not directly apply to your skin. Instead, this product should be added to a formulation at the recommended usage rate.

For external use only, all products are cosmetic grade.

The Food and Drug Administration has not evaluated the statements contained herein. This product is not intended to diagnose, treat, cure or prevent disease. Always consult with your professional skin care provider.

California Prop 65 Statement: The following statement is made to comply with the California Safe Drinking Water and Toxic Enforcement Act of 1986. This product is not known to the State of California to cause cancer, birth defects, or other reproductive harm.

Intro music

Slide 1:
Anti-Aging Solutions
Rejuvenate with Skin Smoothing Matrixyl® Synthe'6®.

Slide 2:
Video of what it is.
Boost any skincare product's effectiveness.
Simply add 18 drops of Matrixyl® Synthe'6® to a 1-ounce base, custom formula, or existing product for a 2% concentration.

Slide 3:
Highest Quality Anti-Aging Peptide for Making Skincare
Matrixyl® Synthe'6® or Palmitoyl Tetrapeptide-38 is an amazing new peptide for your favorite serum or moisturizer!

Slide 4:
Matrixyl® Synthe'6® Benefits -
Anti-aging
Smooths and fills in the look of fine lines and wrinkles
Targets forehead lines, expression lines, and crow's feet

Slide 5:
Skin Perfection Logo
Supercharge your skin with the highest quality anti-aging peptides.

Outro music

INGREDIENTS MATTER.

A cutting-edge peptide blend, promotes healthy collagen, improves skin elasticity, and targets multiple signs of aging, resulting in visibly smoother, plumper, and rejuvenated skin.
Palmitoyl Tetrapeptide 38

Customer Reviews

Questions & Answers

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  • Which one is better, Matrixyl 3000 or Matrixyl Synthe-6?

    Comparing the two peptides is like comparing apples to oranges. Yes, they are both peptides that promote a youthful complexion, but they work differently. Matrixyl Synthe-6 fills in the look of wrinkles and Matrixyl 3000 regenerates skin tone. You can read more about Matrixyl 3000 vs Matrixyl Synthe-6 here: https://www.naturalorganicskincare.com/matrixyl-3000/

  • Can I use this twice per day, morning and night? Can I put this in the Ageless Advanced Moisturizer & the Ultimate Moisturizer?

    Yes, you can use Matrixyl Synthe-6 twice a day. You can add it to any moisturizer included the Aageless or Uultimate.

  • How many drops of Matrixyl Synthe-6 should I add to Liquid Facelift? To Ageless Moisturizer?

    For a 2% concentration of Matrixyl Synthe 6, add 18 drops into a 1 ounce base (Liquid Facelift or Ageless Moisturizer is 1 ounce).

  • Hi. I received the Matrixyl Synthe-6 approximately one month ago and did not refrigerate. It was opened yesterday, and as of today, it is being refrigerated. Should it not be used? Thank you.

    No problem! Matrixyl Synthe-6 can be stored at room temperature. We recommend the fridge for long term storage because most people make a formula and then don’t use the rest for a few months. Keeping it in the fridge keeps it fresh long term.

  • Can I add the Matrixyl Synthe 6 serum booster to my Glow Maker Serum (containing Vitamin C, E, Feurlic acid and Hyaluronic acid)?

    Yes, you can add Matrixyl Synthe-6 to any serum that contains Vitamin C, E, Feurlic acid and Hyaluronic acid.

  • Can matrixyl 6 mixed with matrixyl 3000?

    Yes, you can use Matrixyl Synthe-6 with Matrixyl 3000.

Recommended Products

Frequently Asked Questions

What does Matrixyl Synthe-6 do for your skin?
Matrixyl Synthe-6 is a targeted peptide booster that helps reduce the visible appearance of fine lines and supports collagen production. Chemically known as palmitoyl tetrapeptide-38, it is formulated to act as a topical wrinkle filler around forehead lines and crow's feet while signaling dermal cells to promote matrix proteins that firm and smooth skin. In practical terms Skin Perfection recommends using it at a 2 percent concentration so the active is present at an effective, measurable level; our .5 ounce bottle contains roughly 300 drops to support multiple DIY batches. This product benefits ingredient-savvy users aged 35 to 65 who want clinical-strength, targeted anti-aging results and prefer to boost or customize their own serums and moisturizers. Note that peptides work over weeks, so consistent application and pairing with sun protection will produce the most reliable improvements.
What should you not mix Matrixyl with?
Do not combine Matrixyl Synthe-6 directly into low pH exfoliants or strong oxidizing agents because those conditions can destabilize or break down peptide molecules. Specifically, very acidic formulations such as concentrated AHAs or BHA peel solutions and high strength oxidizers like benzoyl peroxide or unbuffered L-ascorbic acid at low pH can reduce peptide efficacy. Also avoid formulating it with high alcohol content or harsh surfactants that can denature peptides or strip the product vehicle. For best results add Matrixyl Synthe-6 at the recommended 2 percent into neutral-pH serums or bases, store the blue glass bottle refrigerated to preserve activity, and if you use potent actives like vitamin C or strong exfoliants, layer them at different times of day rather than mixing into the same product. Always patch test new combinations.
How long will it take to see results when I use Matrixyl Synthe-6 at 2 percent?
You can typically expect to notice measurable improvements in skin texture and line appearance within 4 to 12 weeks when using Matrixyl Synthe-6 consistently at a 2 percent concentration. Peptide-driven changes rely on cellular signaling that builds extracellular matrix components over time, so visible smoothing and a reduction in expression lines generally appear after several weeks of daily use. Using the serum booster correctly in a stable, neutral-pH base, pairing it with humectants like hyaluronic acid, and protecting skin from UV exposure will shorten the time to visible benefit. Individual results vary based on age, baseline skin condition, and the formulation you boost, and more dramatic changes may require continued use beyond 12 weeks.
Can I add Matrixyl Synthe-6 Serum Booster to my existing skincare products for customized results?
Yes, you can directly add Matrixyl Synthe-6 Serum Booster to your favorite serums, moisturizers, or homemade skincare formulations for tailored anti-aging benefits. This booster contains clinical-strength Palmitoyl Tetrapeptide-38 at a recommended 2% usage rate, allowing you to achieve professional-grade wrinkle-filling and firming results without unnecessary fillers or parabens. One .5-ounce bottle provides about 300 drops, enough to customize over 16 one-ounce batches. Ingredient-savvy women ages 35 to 65 who want to increase the potency of their current routine—especially for addressing crow's feet and forehead lines—will see the most benefit from this DIY approach. For best results, always mix with compatible, water-based products and store the mixture in a cool, dark place; very oily or anhydrous bases may not blend well with peptide boosters.
Is Matrixyl Synthe-6 safe for sensitive skin, and how does it compare to regular Matrixyl 3000 serum boosters?
Yes, Matrixyl Synthe-6 is generally safe for sensitive skin, thanks to its paraben-free formula and absence of harsh fillers or fragrances often found in department-store brands. Unlike regular Matrixyl 3000 serum boosters, Matrixyl Synthe-6 (palmitoyl tetrapeptide-38) targets six skin-rebuilding essentials, offering enhanced wrinkle-filling and firming effects with a recommended 2% usage rate. This concentrated, pure peptide blend is ideal for ingredient-savvy women looking for visible results around the forehead, crow’s feet, and lip lines without irritation. While most users notice smoother, plumper skin with consistent use, those extremely reactive to actives should always perform a patch test first or consult a dermatologist. For maximum anti-aging benefit, Matrixyl Synthe-6 delivers professional-level results in your own customizable routine, outpacing traditional, lower-concentration peptide serums.