Anti Aging Serums

Our serums use the highest concentrations of the best peptides to help turn back the clock. Discover the difference of multple petides in effective concentrations. Our high-performance serums work fast for visibly smoother complexions.

Showing 13 of 13 products

How to Choose an Anti-Aging Serum

An anti-aging serum is a light, concentrated formula applied after cleansing and before moisturizer. Pick one by your main goal: peptides for the look of expression lines and firmness, retinol for overnight renewal, niacinamide for uneven tone, and hyaluronic acid for plumping hydration. Every Skin Perfection serum below lists its full ingredient list on the product page, so you can see exactly which actives you are getting.

Shop by Goal

Compare the Serums in This Collection

Serum Key actives Best for Price
Wrinkle Eraser Supercharged Peptide Serum Argireline, Snap-8, Matrixyl 3000, Inyline, Syn-Ake, Pepha-Tight, Uplevity The most peptides in one bottle $99.95 (0.5 oz)
Super Peptide Anti-Aging Serum Acetyl Hexapeptide-8, Acetyl Octapeptide-3, Pentapeptide-18, Palmitoyl Tripeptide-1 and Tetrapeptide-7, Palmitoyl Tripeptide-5 All skin types, twice daily $149.95
Peptide Fusion Anti Aging Collagen Serum Snap-8, Argireline, Syn-Tacks, Syn-Coll, apple stem cells Lines plus firmness $89.95
Ageless Advanced Age-Defying Serum Snap-8, Syn-Ake, Matrixyl Synthe-6, Adipofill'in, Haloxyl Expression lines and the look of volume $79.95
Liquid Facelift Collagen Serum Uplevity, Argireline, Matrixyl 3000, Pepha-Tight, retinol complex Night use, lifted look $74.95
20% Matrixyl 3000 Collagen Serum Matrixyl 3000, Pepha-Tight, DMAE A focused firming step $49.95 (0.5 oz)
Neck Lift and Firm Serum Pepha-Tight, Relistase, Matrixyl 3000, Syn-Coll Neck and décolleté $49.95
Expression Line Deep Wrinkle Serum Snap-8, Argireline, Syn-Ake, Matrixyl 3000, Renovage Forehead and frown lines $46.95 (0.5 oz)
Youth Serum Collagen Peptide Relistase, Matrixyl 3000, Regu-Age, Syn-Coll, Teprenone Firmness, pairs with Expression Line $38.50 (0.5 oz)
2.5% Retinol Serum 2.5% retinol concentration, botanical hyaluronic acid, green tea Night renewal, non-sensitive skin $32.95
Ultra Hyaluronic Plumping Gel Sodium hyaluronate Plumping layer over serums From $31.95
Hyaluronic Acid Plumping Serum Hyaluronic acid, radish root ferment Hydration for every skin type From $29.95
10% Niacinamide Serum 10% niacinamide, zinc PCA Uneven tone, oily or combination skin $24.95

What the Research Shows

  • Argireline: in a study of 10 women, a cream with 10% Argireline reduced measured wrinkle depth by up to 30% after 30 days (Blanes-Mira, 2002).
  • Matrixyl 3000: in Sederma's supplier study, women using 3% twice daily for 2 months on one half of the face saw a 39.4% decrease in the surface occupied by deep wrinkles from the start, while the placebo side showed no significant change (supplier data).
  • Retinol: in a 24-week study of 36 older adults, 0.4% retinol lotion improved fine wrinkle scores compared with a plain lotion (Kafi, 2007).
  • Niacinamide: in a 12-week split-face study of 50 women, 5% niacinamide improved the look of fine lines, spots, and sallowness (Bissett, 2005).
  • Hyaluronic acid: in a 60-day study of 76 women, 0.1% hyaluronic acid creams improved hydration and elasticity (Pavicic, 2011).

How to Use Serums Together

  1. Cleanse and tone. Apply serums to slightly damp skin.
  2. Layer thinnest to thickest: a peptide serum first, then a hyaluronic acid layer, then moisturizer.
  3. Morning: peptides, niacinamide, hyaluronic acid, then sunscreen. In a 4.5-year trial of 903 adults, daily sunscreen users showed 24% less skin aging than discretionary users (Hughes, 2013).
  4. Night: retinol products such as the 2.5% Retinol Serum or Liquid Facelift. Start every other night. Peptide serums can be layered first; see how to combine retinol and peptides.

Sensitive skin: patch test on the inner arm for 24 hours, start with one product used once a day, and skip retinol formulas until your skin tolerates the rest. For a deeper buying guide, read Top Anti-Aging Serums: Peptides and Antioxidants.

Frequently Asked Questions

What is the most effective anti-aging serum?

There is no single best serum for everyone. Peptides, retinol, niacinamide, and hyaluronic acid each have human studies behind them, so choose the one that matches your main concern. Multi-peptide formulas such as the Wrinkle Eraser combine several actives in one step.

At what age should I start using an anti-aging serum?

There is no fixed age. Hydrating serums suit any adult, and peptides or retinol are usually added once fine lines begin to show. Daily sunscreen matters at every age.

Should I use an anti-aging serum morning or night?

Peptide, niacinamide, and hyaluronic acid serums can be used morning and night. Retinol serums belong at night, followed by sunscreen the next morning.

Can I use more than one serum at a time?

Yes. Apply the thinnest first, let each one absorb for a minute or two, and finish with moisturizer. Keep to two or three serums so each layer absorbs well.

How long does it take to see results?

Hydration is visible right away. The studies above measured changes in the look of lines at 30 days to 24 weeks, so give a serum at least 8 weeks of steady use.

Do I still need a moisturizer after a serum?

Usually, yes. A moisturizer helps hold water in the skin over the serum layer, especially for dry or mature skin.

Sources

  • Blanes-Mira C, Clemente J, Jodas G, et al. A synthetic hexapeptide (Argireline) with antiwrinkle activity. International Journal of Cosmetic Science. 2002;24(5):303-310. doi:10.1046/j.1467-2494.2002.00153.x
  • Sederma, Matrixyl 3000 technical document (supplier data).
  • Kafi R, et al. Improvement of naturally aged skin with vitamin A (retinol). Archives of Dermatology. 2007;143(5):606-612. PubMed 17515510
  • Bissett DL, Oblong JE, Berge CA. Niacinamide: a B vitamin that improves aging facial skin appearance. Dermatologic Surgery. 2005;31(7 Pt 2):860-865. doi:10.1111/j.1524-4725.2005.31732
  • Pavicic T, et al. Efficacy of cream-based novel formulations of hyaluronic acid of different molecular weights in anti-wrinkle treatment. Journal of Drugs in Dermatology. 2011;10(9):990-1000. jddonline.com
  • Hughes MCB, et al. Sunscreen and prevention of skin aging: a randomized trial. Annals of Internal Medicine. 2013;158(11):781-790. doi:10.7326/0003-4819-158-11-201306040-00002

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

About the Author
Written by Kari Thomas, cosmetic formulator and founder of Skin Perfection.