Argireline, Acetyl Hexapeptide 8

Argireline is Acetyl Hexapeptide-8, the peptide most associated with the look of expression lines: forehead creases, crow's feet, and the 11s between the brows. Blend it into your base at 10%, the manufacturer's highest recommended rate.

This is a formulation ingredient, not a finished serum. Do not apply it undiluted.

What is in the bottle

INCI: Water, Acetyl Hexapeptide-8, Caprylyl Glycol

Three ingredients. Caprylyl glycol is the preservative.

Clear liquid. Water-soluble. Fragrance-free, paraben-free. 0.5 oz blue glass dropper bottle.

The science: Acetyl Hexapeptide-8 and the SNARE complex

Argireline is a six-amino-acid sequence, first described in 2002 by Blanes-Mira and colleagues in the International Journal of Cosmetic Science, and one of the most studied cosmetic peptides in use.

The published research centers on the SNARE complex, the protein assembly that mediates signaling at the neuromuscular junction. Acetyl Hexapeptide-8 has been studied for its interaction with SNARE complex formation, which is why it is grouped with the expression-line peptides rather than the collagen-support ones.

In a randomized, placebo-controlled study of 60 adults (Wang et al., American Journal of Clinical Dermatology, 2013), Argireline was applied twice daily to the lines around the eyes for 4 weeks. Visual grading showed a total anti-wrinkle efficacy of 48.9% in the Argireline group and 0% in the placebo group, and roughness measured on silicone skin replicas decreased in the Argireline group. The study abstract does not state the concentration used.

The supplier's efficacy work reports improved appearance of fine lines at a 2% concentration, with measured reductions in wrinkle depth and volume.

The supplier findings are the manufacturer's, from their efficacy dossier, and we reproduce them here under our license agreement. Published and supplier studies describe testing of the ingredient, not of a finished product you blend at home.

How much to add

We recommend 10%, the manufacturer's highest recommended rate, so you see results sooner. Using our house rate of 9 drops per 1% per fluid ounce:

See the serum booster chart for full conversions. Every order includes an instruction guide and chart.

How to use it

1. Choose a water-based serum, gel, lotion, or cream. Hyaluronic acid serum is the usual base.
2. Add 90 drops per ounce of base (10%).
3. Cap and shake well.
4. Refrigerate what you are not using.
5. Apply the finished blend morning and night to the forehead, around the eyes, and the lip area.

How to make a 10% Argireline solution at home

A 10% Argireline solution is one of the most searched peptide formats. You can make your own in about two minutes, and you will know the exact concentration because you counted it in.

1. Sanitize a dropper bottle and your work surface.
2. Pour in the hyaluronic acid serum. Use a preserved base like ours, not plain water, so the finished blend stays fresh.
3. Count in 90 drops of Argireline per ounce, or weigh 3.0 g per ounce for accuracy.
4. Cap, shake well, and label the bottle with "10% Argireline" and the date.
5. Refrigerate and apply morning and night.

At 10%, one 0.5 oz bottle of Argireline makes about 5 oz of finished serum.

Argireline and Matrixyl 3000 in one serum

Argireline is used for the look of lines that come from movement. Matrixyl 3000 (Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7) is used for the look of firmer, better-supported skin overall. They do different jobs, which is why formulators so often pair them.

Add both to 1 oz of hyaluronic acid serum, cap and shake. We recommend each peptide at the manufacturer's highest rate, 10% for Argireline and 8% for Matrixyl 3000, so you see results sooner.

Prefer a ready-made Matrixyl base? Add 90 drops of Argireline per ounce (10%) to our 20% Matrixyl 3000 Collagen Serum.

A note on evidence: each peptide has its own published or supplier testing. We have not found a published trial that tested these two together, so this pairing is formulation logic, not a tested combination claim.

What it is for

Argireline is formulated for the lines that come from movement rather than sun or slack, the ones that deepen because your face makes the same shapes every day.

• Forehead creases
• The 11s between the brows
• Crow's feet at the outer corners of the eyes
• Fine lines around the mouth

For firmness across the whole face rather than specific lines, Matrixyl 3000 is the one to reach for instead. They layer well together.

Why buy it raw

Finished products naming this ingredient rarely tell you how much is in them, and it is usually less than you would choose. Blend it yourself and the number is yours, because you counted the drops in.

At 10%, one 0.5 oz bottle blends about 5 oz of finished serum.

Blending with other peptides

Argireline layers with Snap-8, Syn-Ake, and Inyline. Each works on the look of expression lines through a different route, so combining them doesn't double up on the same thing. Keep the combined total sensible: the base still has to be mostly base.

Want the newer version of this peptide, used at a lower rate of 5%? See Argireline Amplified.

Storage

Refrigerate on arrival. The blue glass keeps light out.

Sources

• Blanes-Mira C, et al. A synthetic hexapeptide (Argireline) with antiwrinkle activity. International Journal of Cosmetic Science 24(5):303-310, 2002. doi:10.1046/j.1467-2494.2002.00153.x
• Wang Y, Wang M, Xiao S, Pan P, Li P, Huo J. The anti-wrinkle efficacy of Argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study. American Journal of Clinical Dermatology, 2013. PubMed 23417317

For external use only. Cosmetic grade. Do not apply undiluted to skin. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Argireline is a registered trademark of Lipotec S.A.U., used under license.

What is Argireline?
Argireline is the most trusted anti-aging peptide. It is one of the most popular, widely used, and reputable anti-wrinkle peptides used in the skincare industry.
Is Argireline a good alternative to botox?
Argireline is considered one of the best botox alternatives! Argireline relaxes your expression line facial muscles whereas Botox paralyzes those muscles. Both result in a reduction of fine lines and wrinkles.
Does this product need to be refrigerated?
We recommend placing Argireline in your fridge to keep it fresh for the next time you need it.

INCI: Water (and) Acetyl Hexapeptide-8

Recommended Usage Rate: 2-10%

Place in the refrigerator upon arrival.

Color: Colorless

Appearance: Clear liquid

Solubility: Water-soluble

pH: 3.0-6.0

Scent: No fragrance, unscented

Storage: Refrigerate

Shelf-life: 12 months after opening

Country of Origin: Spain

Raw Material: Plant-based

Animal Testing: Cruelty-free

GMO: Non-GMO

Vegan: Yes

CAS: 616204-22-9

HS Code: 3504.00

Acetyl Hexapeptide-8 is a peptide that targets the formation of wrinkles by reducing contractions. It also helps reduce the appearance and depth of expression lines.

We recommend a 2-10% concentration when mixing the Argireline® Peptide Solution into any existing skincare product or adding it to your recipe at home. With your current product, blend the Argireline® Peptide Solution into the product until you have a uniform mixture.

If you're creating a lotion, serum, or moisturizer at home, be sure to add your Serum Booster drops during the water phase.

For a 10% concentration of Argireline in a 1-ounce skincare product, bulk base, or formula, add 90 drops.

For a 2% concentration of Argireline in a 2-ounce skincare product, bulk base, or formula, add 36 drops.

Included is our product instruction guide on how to add serum boosters to your formula. Argireline® Peptide Solution works excellent with other anti-wrinkle peptides. For example, Snap-8™ Peptide, Inyline® Peptide, and Syn®-Ake are great candidates. Using a blend of peptides can maximize their skincare benefits.

Formulation: Add transparent liquid at the end of the formulation. You can also add it to the water phase. This peptide is super easy to incorporate. It is a clear liquid that has the consistency of water. It is fragrance-free and will not change the product scent.

When used at high concentrations, as with all ingredients, the formula you are adding it to may get thinner.

Size: .5 ounce of Argireline® Peptide Solution NP (non-paraben), protected from light by a blue glass bottle with a dropper.

Place in the refrigerator upon arrival.

Argireline® Peptide Solution is an anti-wrinkle active used in serum making. Do not apply directly to the skin.

Sample Recipes

If you're not sure how to add a serum booster to one of your favorite skincare products, you might be nervous about trying it for the first time. We're here for you! We've made a helpful video to walk you, step-by-step, through the process of adding a serum booster to an existing product.

Are you feeling adventurous? Making skincare products is fun and a lot easier than you might think! Check out our recipe for a supercharged anti-aging serum with an Argireline boost or how to make your own Argireline Peptide face cream.

Applications:

• Anti-Aging Day and Night Moisturizers
• Anti-Aging Face Serums
• Body Butters
• Eye Creams and Gels
• Facial Mists, Toners, or Astringents
• Highly Concentrated Back Bar Facial Treatments
• Hyaluronic Facial Serums
• Lotions and more!

MSDS Sheet

Lipotec Active Ingredients

850061380104

Do not directly apply to your skin. Instead, this product should be added to a formulation at the recommended usage rate.

For external use only, all products are cosmetic grade.

The Food and Drug Administration has not evaluated the statements contained herein. This product is not intended to diagnose, treat, cure, or prevent disease. Always consult with your professional skincare provider.

California Prop 65 Statement: The following statement is made to comply with the California Safe Drinking Water and Toxic Enforcement Act of 1986. This product is not known to the State of California to cause cancer, birth defects, or other reproductive harm.

Argireline® Peptide Solution is a registered trademark of Lipotec S.A. or its affiliates.

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Slide 1:
Anti-Aging Solutions
Rejuvenate with Youth-Boosting Argireline® Peptide

Slide 2:
Video of what it is.
Boost any skincare product's effectiveness. Simply add 90 drops of Argireline® Peptide to a 1-ounce base, custom formula or existing product for a 10% concentration.

Slide 3:
Highest Quality Anti-Aging Peptides for Making Skincare
Reduce the appearance of fine lines and wrinkles and visibly smooth your complexion.

Slide 4:
Benefits of Argireline® Peptide -
Anti-aging
Anti-wrinkle
Expression lines
Fine lines and wrinkles

Slide 5:
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Supercharge your skin with the highest quality anti-aging peptides.

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