Argireline Amplified Peptide Serum Booster

Argireline® Amplified Peptide Solution is the newest multifunctional anti-aging ingredient on the market.

This all-in-one anti-aging peptide is the best multifunctional peptide to make your skin glowing and look more youthful.

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Argireline Amplified is a peptide serum booster that reduces expression lines by relaxing facial muscles and minimizing post-expression time. It delivers clinical-strength 25% Argireline in a liposomal system for deeper penetration and faster visible results.

If you struggle with forehead lines, crow's feet, or persistent expression wrinkles, this booster helps reduce wrinkle depth and improve firmness without injections. A 3D bio-printed muscle model study led by Dr. Samuel Sánchez at the Institute of Bioengineering of Catalonia demonstrated measurable muscle relaxation. It reduced post-expression time with the amplified peptide formulation.

  • Clinical-strength 5% Argireline Amplified concentration for rapid expression-line reduction
  • Studies report up to a 20% reduction in wrinkle depth within 28 days with amplified formulations.
  • Liposomal delivery for deeper skin penetration and increased efficacy compared to standard topical peptides
  • Developed with green chemistry principles and formulated paraben-free for daily topical use

Use this booster under your serum or mix it into DIY formulations to target specific areas, such as the forehead, eyes, and lip lines. Unlike original Argireline, which offers gradual improvement, this amplified solution is engineered for faster, larger changes in wrinkle depth and skin firmness while remaining a topical alternative to injectables.

Tested in bioengineered models and supported by comparative studies, this peptide booster is presented with transparent ingredient information so you can customize use with confidence. Learn more about the application and research references to ensure it fits your routine.

Erasing Expression Lines

Expression lines are age-associated and usually appear in our early 30s. Argireline Amplified Peptide Solution, or "Amp," lessens the appearance of expression lines by relaxing facial muscles and minimizing post-expression time.

Clinical Studies

Argireline® Amplified Peptide Solution delivers superior results, helping you look five years younger in a short time. As a result, skin roughness, facial volume, or radiance was improved.

In addition, this multifunctional skincare ingredient showed greater effectiveness over the original Argireline® Peptide.

3D bio-printed muscle model shows the relaxation activity and post-expression time. Expert Dr. Samuel Sánchez led this study from the Institute of Bioengineering of Catalonia.

Benefits of Argireline Amplified Peptide:

  • Diminishes the appearance of expression wrinkles
  • Improved firmness and elasticity
  • A smoother, softer complexion that is more visibly radiant
  • Improved firmness and elasticity
  • Increased volume for a more supple appearance
  • Skin-lifting effect
  • Minimalist beauty, minimal products with better results
  • Made with green chemistry-based principles
  • Delivers all the benefits of original Argireline, but with significantly enhanced potency and efficacy.
  • Penetrates deeper into the skin due to its smaller molecular size and advanced delivery systems (such as liposomes).
  • It provides faster, more visible results, with some studies showing up to a 20% reduction in wrinkle depth in just 28 days, and claims of making skin look five years younger in just 5 days with higher concentrations.
  • Offers a skin-lifting effect and improved skin volume, contributing to a more youthful appearance.

Benefits of Argireline (Original):

  • Reduces the appearance of fine lines and wrinkles, especially those caused by facial expressions.
  • It supports collagen production and improves skin firmness and elasticity over time.
  • Offers a gentle, gradual improvement for those new to peptide-based skincare.
  • Costs less.

Argireline® Amplified Peptide Solution VS Argireline® Peptide Solution

Our favorite hexapeptide, Argireline® Peptide Solution, was the first to target expression lines on the market. After years of use, it is still one of the best peptides.

Argireline® Amplified Peptide Solution is the new, evolved version designed using green chemistry and minimalist principles. It provides improved results, minimizing expression lines before and after facial muscle contractions.

  • Core Mechanism: Argireline and Argireline Amplified are peptides (specifically, acetyl hexapeptide-8) that reduce muscle contractions in the skin, thereby minimizing expression lines and wrinkles. They act as neurotransmitter inhibitors, targeting the SNARE complex to relax facial muscles and smooth the skin.
  • Topical Application: Both are non-invasive, topical alternatives to injectable treatments like Botox, making them appealing for those seeking needle-free anti-aging solutions.
  • Safety: Both are considered safe for most skin types and daily use, with minimal risk of severe side effects.

Why Argireline Amplified Is Considered Better

  • Superior Efficacy: Argireline Amplified is engineered to be up to 50 times more potent than the original, delivering dramatic, faster improvements in wrinkle depth, skin firmness, and radiance.
  • Enhanced Penetration: Its smaller molecular size and advanced delivery systems enable it to penetrate deeper into the skin, maximizing its anti-aging effects.
  • Comprehensive Benefits: Beyond reducing wrinkles, it improves skin volume, elasticity, and overall radiance, offering a more holistic rejuvenation8910.
  • Longer-Lasting Effects: Improved molecular stability means results last longer and are more consistent over time.

Who Should Use Which?

Choose Argireline Amplified if:

  • You want faster, more visible anti-aging results.
  • Your primary concern is expression lines (forehead, eyes, crow's feet).
  • You prefer advanced, high-performance skincare ingredients.
  • You want comprehensive benefits, including lifting, firming, and added radiance.

Choose Original Argireline if:

  • You are new to peptides and want to start with a classic, proven formula.
  • Your skin is sensitive, and you prefer a milder approach.
  • You are focused on general wrinkle prevention rather than rapid transformation.

Argireline Amplified is generally considered the superior choice for most users seeking visible, fast, and comprehensive anti-aging results, thanks to its advanced formulation, deeper skin penetration, and greater potency. However, both peptides are effective, safe, and non-invasive, making them excellent options for anyone looking to reduce wrinkles and improve skin health. In addition, they help mitigate age-associated changes and increase suppleness, smoothness, and radiance. It's truly an all-in-one peptide.

EWG Score

The Skin Deep® ingredient hazard score, from 1 to 10, reflects known and suspected hazards linked to the ingredients. Learn more →
1-2 Low Hazard
3-6 Moderate Hazard
7-10 High Hazard

  • Water (Aqua) Origin:
  • Acetyl Hexapeptide-8 Origin:
  • Sodium Benzoate Origin:

What is the difference between Argireline Amplified Peptide and Argireline Peptide?
Our favorite hexapeptide Argireline® Peptide Solution was the first peptide on the market to target expression lines and after years of use, it is still one of the best peptides around.
Argireline® Amplified Peptide Solution is the new, evolved version designed with green chemistry-based and minimalist principles. As a result, it provides improved results, minimizing expression lines before and after facial muscle contractions.
How does Argireline Amplified work?
Argireline® Amplified Peptide Solution or "Amp" lessens the appearance of expression lines by relaxing facial muscles and minimizing post-expression time.
Does this product need to be refrigerated?
We recommend placing Argireline Amplified in your fridge to keep it fresh for the next time you need it.
What is Argireline Amplified and how does it work?
Argireline Amplified is an advanced version of the original Argireline peptide (acetyl hexapeptide-8), engineered with smaller molecules for deeper skin penetration and increased potency. It works by inhibiting the SNARE complex involved in neurotransmitter release, which reduces facial muscle contractions that cause expression wrinkles. Additionally, it stimulates collagen production, improving skin firmness and elasticity. This dual-action—relaxing muscles and boosting collagen—helps smooth existing wrinkles and prevent new ones, offering a non-invasive alternative to Botox.
How is Argireline Amplified different from regular Argireline or Botox?
Argireline Amplified is more potent than standard Argireline, with enhanced skin penetration and stability, making its effects longer-lasting. Unlike Botox, which is injected and provides immediate, dramatic results by paralyzing muscles, Argireline Amplified is a topical solution that offers more gradual, milder effects without injections or the risk of frozen facial expressions. It is also the first peptide specifically designed to target expression wrinkles topically.
Is Argireline Amplified safe to use, and are there any side effects?
Argireline Amplified is generally considered safe for most skin types and suitable for daily use. Side effects are rare but may include temporary redness, irritation, dryness, or allergic reactions, especially in sensitive individuals. Patch testing is recommended before widespread use. It does not carry the risk of severe side effects like those associated with injectable neuromodulators.
How long does it take to see results with Argireline Amplified?
Visible improvements in fine lines and wrinkles can appear within a few weeks of consistent use, but full benefits may take several weeks to months, depending on individual skin characteristics and product concentration. Patience and consistency are essential for optimal results.
Can Argireline Amplified be used with other skincare products and on all areas of the face?
Yes, Argireline Amplified can be layered with other serums and skincare products, but it should be applied first and allowed to absorb before adding other actives.
It is safe for use around the eyes (with caution to avoid direct contact), and daily application is recommended for ongoing benefits. Always monitor for irritation, especially when combining with potent actives like retinol or vitamin C.

INCI: Water (aqua), Acetyl Hexapeptide-8, Sodium Benzoate

Recommended Usage Rate: 2-5%

Place in refrigerator upon arrival.

Appearance: Clear, thin liquid

Solubility: Water-soluble

Storage: Store in a cool, dry place

Shelf-life: 12 months after opening

Country of Origin: Spain

Raw Material: Plant-based

Animal Testing: Cruelty-free

GMO: Non-GMO

Vegan: Yes

CAS: 616204-22-9/532-32-1

HS Code: 3504.00

For a 5% concentration of Argireline® Amplified Peptide in a 1-ounce skincare product, bulk base, or formula, add 45 drops.

For a 2% concentration of Argireline® Amplified Peptide in a 2-ounce skincare product, bulk base, or formula, add 36 drops.

Size: .5-ounce blue glass bottle with a dropper lid for easy dispensing.

Applications:

  • Anti-Aging Face Creams
  • Anti-Aging Moisturizers
  • Anti-Aging Serums
  • Body Lotions
  • Day and Night Moisturizers
  • Eye Creams and Gels
  • Facial Masks
  • Firming Body Lotions
  • Highly Concentrated Back Bar Facial Treatments
  • Make-up Including Foundation
  • Multifunctional Serums
  • Tightening Eye Creams, Eyelash, Eyebrow Formulas, and more!

MSDS Sheet

Lipotec Active Ingredients

850061380111

Do not directly apply to your skin. Instead, this product should be added to a formulation at the recommended usage rate.

For external use only, all products are cosmetic grade.

The Food and Drug Administration has not evaluated the statements contained herein. This product is not intended to diagnose, treat, cure, or prevent disease. Always consult with your professional skincare provider.

California Prop 65 Statement: The following statement is made to comply with the California Safe Drinking Water and Toxic Enforcement Act of 1986. This product is not known to the State of California to cause cancer, birth defects, or other reproductive harm.

Argireline® Amplified Peptide Solution is a trademark of Lipotec S.A. or its affiliates.

Intro music

Slide 1:
Anti-Aging Solutions
Rejuvenate with Youth-Boosting Argireline® Amplified Peptide

Slide 2:
Video of what it is.
Boost any skincare product's effectiveness. Simply add 45 drops of Argireline® Amplified Peptide to a 1-ounce base, custom formula or existing product for a 5% concentration.

Slide 3:
Highest Quality Anti-Aging Ingredients for Making Skincare
This all-in-one anti-aging peptide is the best multifunctional peptide to get your skin glowing and you looking more youthful.

Slide 4:
Benefits of Argireline® Amplified Peptide -
Diminishes the appearance of expression wrinkles
Skin-lifting effect with improved firmness and elasticity
Smoother, softer complexion that is more visibly radiant
Increased volume for a more supple appearance
Made with green chemistry-based principles

Slide 5:
Skin Perfection Logo
Supercharge your skin with the highest quality anti-aging peptides.

Outro music

INGREDIENTS MATTER.

Amp up your Argireline Peptide Serums with anti-aging ingredients that really work.
Acetyl Hexapeptide-8

Customer Reviews

Questions & Answers

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  • I want to add 10% Argireline Amplified concentration into a cream base. if the cream is 30 gm, how many drops of it would I add? How much of the peptide solution would I add to make a 10% concentration in a 30 ml cream base?

    To make a 10% concentration in a 30 ml or 1-ounce cream base, you would add 90 drops of Argireline Amplified peptide. (90 drops equals 3/4 teaspoon plus 15 drops)

  • What is the difference between this Argireline Amplified and the regular one? Thanks!

    Argireline Amplified is one of the newest anti-aging peptide. It is more powerful than the original Argireline. It is "multifunctional" and targets multiple signs of aging, not just wrinkles. If you like Argireline in your skincare products, you will love the "Amped" version.

  • Should argireline plus be refrigerated

    Yes, we recommend storing Argireline Amplified in the refrigerator. The fridge will keep it fresh for the next time you use it. You can also write the "use by" date (the date opened plus 12 months) on the label with a permanent marker.

  • How do I add Argireline® Amplified to my current moisturizer? I use "Just Nutritive," and the pump bottle is 8 ounces. How much Argireline should I add to the bottle? And how to stir/mix? Any advice would be most appreciated. Best, Jill

    All of our serum boosters, including Argireline Amplified come with an instruction booklet. It includes a step-by-step guide and chart so that you can quickly and easily calculate the amount of booster you will need to add. First, determine the amount needed. The manufacturer recommends using the peptide at a 5% concentration. This information can be found on the label. You can also find it on the product listing page. For an 8 ounce bottle, that would be 360 drops. Each .5 ounce bottle has approximately 300 drops. You will need to use 2 bottles or you can add a 1 ounce of the lotion to an airless pump bottle and then add 45 drops of Argireline Amplified. Second, mix until well blended. You can use a handheld blender or stir stick. For tips and tricks or to watch our "How To" Tutorial Video Series click the link.

  • How much product is in a bottle of your Argireline Amplified Peptide, and how many drops in a bottle? I was surprised it’s not listed given you offer thorough information on the ingredients and amounts to use in skincare products.

    Each bottle is .5 ounce or 15 ml. There are approximately 300 drops in each bottle.

  • I want to know which is more effective for expression lines, marionette lines, forehead lines and laugh lines Argireline amplified or Snap 8?

    Thank you for reaching out with your question about the best options for addressing expression lines, including marionette lines, forehead lines, and laugh lines. Both Argireline Amplified and Snap-8 are excellent peptides known for their anti-aging effects, particularly in reducing the appearance of expression lines. Here’s a brief overview to help you decide which might be more suitable for your needs:

    Argireline Amplified is a newer and more potent form of the original Argireline, designed to target expression wrinkles more effectively. It works by modulating the formation of the SNARE complex, thus reducing muscle contractions that lead to expression lines. Due to its enhanced action, Argireline Amplified can provide visible smoothing and softening of wrinkles and is particularly effective for areas like the forehead and around the eyes.

    Snap-8 is another peptide that complements the action of Argireline by targeting different mechanisms of wrinkle formation. It also helps reduce muscle contractions but with a slightly different approach in the biochemical pathway. Snap-8 is especially useful for deeper expression lines and can be beneficial for areas like marionette lines and laugh lines.

    For comprehensive results, many users find that using both peptides in conjunction can maximize anti-wrinkle benefits, as they work synergistically to reduce muscle movement and can reduce wrinkle formation from different angles. However, if you prefer to start with one, choosing might depend on which areas of your face are your priority:

    • If your concern is primarily with lines around the eyes and forehead, Argireline Amplified might be the better choice due to its potent action in these areas.
    • If you're more concerned about deeper lines around the mouth and lower face, Snap-8 could be more effective.

    Remember, the best approach is also to consider other aspects of skincare, such as hydration, proper sun protection, and overall skin health, to complement the effects of these peptides.

    Please feel free to reach out if you have any further questions or need assistance in selecting products. We're here to help you achieve the best possible results from your skincare routine.

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Frequently Asked Questions

Is Argireline Amplified better than original Argireline?
Yes. Argireline Amplified is generally considered superior to the original Argireline for treating expression lines because it was engineered for higher potency, improved skin delivery, and faster visible results. Specifically, the amplified form is formulated to be significantly more potent (manufacturer data cites up to 50 times greater activity), uses smaller peptide fragments and advanced carriers such as liposomes for deeper penetration, and has published study data showing muscle-relaxation activity in a 3D bio-printed muscle model. This means quicker reduction in post-expression wrinkle time and measurable wrinkle-depth improvements in short-term studies. Ideal users are ingredient-savvy women ages 35–65 who want faster, needle-free reduction of forehead lines and crow’s feet and who are comfortable using concentrated actives. If your skin is very sensitive or you prefer a gentler, slower approach, the original Argireline or starting at a lower concentration may be a better option.
What does the Argireline peptide do?
Argireline (acetyl hexapeptide-8) reduces the appearance of expression wrinkles by modulating the biochemical signals that cause repeated muscle contractions. Mechanistically, it interferes with the SNARE complex involved in neurotransmitter release, which relaxes micro-muscle activity and shortens the time skin remains creased after facial expressions. Clinically, topical Argireline has been shown to reduce fine lines and improve firmness over time, and amplified formulations add deeper penetration and faster visible effects. This makes it a non-invasive alternative to injectable neuromodulators for minimizing dynamic lines. Best beneficiaries are people with expression-related lines (forehead, glabella, crow’s feet) who want gradual, topical improvement. Note that topical peptides work more slowly and less dramatically than injectables, and consistent use and appropriate formulation strength influence outcomes.
How long does it take to see results with Argireline Amplified Peptide?
You can expect initial, visible softening of expression lines within days to a few weeks, with more measurable wrinkle-depth reductions commonly reported by four weeks. Argireline Amplified combines higher potency and advanced delivery (smaller peptide size and liposomal carriers), so early effects on post-expression time and skin smoothness often appear faster than with classic peptide formulas; some controlled studies report up to a 20% reduction in wrinkle depth after 28 days. Deeper improvements in firmness, volume, and collagen support develop over several weeks to months with regular use. Results vary by concentration, frequency of application, skin type, and the severity of lines, so consistent twice-daily use, sunscreen, and complementary hydrators (for example hyaluronic acid) enhance outcomes.
Can I customize the Argireline Amplified Peptide with other serums or DIY boosters in my skincare routine?
Yes, the Argireline Amplified Peptide from Skin Perfection is specifically designed to work seamlessly as a serum booster that you can combine with other anti-aging serums, moisturizers, or your own DIY skincare creations. Its concentrated, filler-free formula allows users to layer it with ingredients like Matrixyl 3000 or hyaluronic acid, targeting expression lines and loss of elasticity while still benefiting from other actives in your regimen. The advanced delivery system ensures deep absorption, making it ideal for ingredient-savvy women who want to achieve clinical-grade results without paying premium prices. This customization is perfect for anyone aiming to create a minimalist, personalized routine that addresses multiple aging concerns. Those with ultra-sensitive skin should patch test new formulations, but most users experience enhanced results and flexibility when integrating the Amplified Peptide with their favorite products.
Is Argireline Amplified Peptide safe for sensitive skin and daily use?
Yes, Argireline Amplified Peptide is generally safe for sensitive skin and can be used daily. The formula is free from fillers, parabens, and artificial fragrances—minimizing the risk of irritation while delivering professional-grade concentrations of Argireline, a peptide clinically proven to reduce wrinkle depth by up to 20% in 28 days. Because it uses advanced green chemistry and a minimalist ingredient list, it's ideal for ingredient-conscious users who want maximum efficacy without compromise. Most Skin Perfection customers with mature or reactive skin find it gentle, thanks to its non-invasive topical action, but as with any potent active, a patch test is still recommended. If you are especially sensitive or new to high-strength peptides, consider starting with the original Argireline formula, which provides proven results in a milder concentration.