Firming Serum Booster with Progeline

Progeline is a highly sought-after peptide to improve the skin's elasticity, facial firmness, sagging jowls, and jawline by blocking progerin.

Restore facial firmness in sagging areas and the jawline by improving elasticity by inhibiting progerin with our Firming Serum Booster with Progeline.

$39.99
OR
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Firming Serum Booster with Progeline is a concentrated peptide booster containing Trifluoroacetyl Tripeptide-2 (Progeline), designed to support collagen production and improve skin firmness where laxity appears.

Suppose you struggle with jawline sagging, loss of elasticity, or fine lines. In that case, this booster is formulated to be added to a hyaluronic acid serum or moisturizer to deliver a targeted active that counteracts progerin-related aging pathways.

  • Contains Trifluoroacetyl Tripeptide 2 (Progeline) to target progerin-associated loss of firmness
  • Mixing guideline: add 18 drops to 1 ounce (30 ml) hyaluronic acid serum for approximately 2% active concentration
  • Glycerin and dextran carriers provide humectant hydration and formulation stability.
  • Vegan paraben-free fragrance-free and cruelty-free formulation
  • Targets fine lines, wrinkles, jawline, jowls, neck, and periocular laxity via collagen support
  • Compatible with DIY serum boosters and professional routines, mixes cleanly into creams and HA bases

Unlike diluted department-store peptide serums that often include fillers, this booster is intended as a concentrated active to be combined into your serum or cream at measurable rates for clearer dosing. Compared to all-in-one creams, this product is for users who want to customize concentration and placement.

Formulated and batch tested by Skin Perfection Natural and Organic Skin Care. Contains documented peptide actives. Follow mixing instructions and consult a dermatologist when using multiple actives or professional-strength regimens.

What Is Progeline?

Progeline™ is a biomimetic peptide that inhibits a protein called progerin. Progerin appears when there is a mutation in our genes, often associated with aging. Aging-related changes in our skin cause wrinkles, sagging, loss of firmness, and decreased elasticity, especially around the jawline and jowls.

In addition, as we age, our skin becomes thinner and doesn't bounce back as easily as it did when we were younger.


We've all heard of collagen. It's what helps your skin appear young and healthy. However, your skin produces collagen more slowly and less collagen as you age.

Blocking Progerin, Delaying Aging

This other protein, progerin, works against the amino acids that promote collagen production. So, Progeline helps block progerin's action, helping your skin age more slowly.

Fewer disruptions result in a younger-looking and feeling complexion. It's a substance full of three potent amino acids, which help your body produce the protein collagen.

The active ingredient in Progeline is trifluoroacetyl tripeptide. Progeline helps block progerin from taking over, resulting in a healthier complexion that can replenish collagen.

And, in turn, slows down your skin's aging process, reducing the visible signs of aging.

What Are the Benefits of Progeline?

Progeline™ is known to help with several physical signs of aging. First, it helps prevent sagging skin by providing a complete remodeling effect. Second, as we age, our jawline and jowls begin to sag.

You will start to see this happen on your face and neck. Anyone with visible signs of aging will benefit from using progeline.

The appearance of fine lines will diminish with the use of progeline. Fine lines and wrinkles begin to appear due to a lack of collagen. Free radicals can cause premature aging.

Progeline helps your skin appear plump and supple. It also promotes cell renewal, rejuvenating aging skin and making it look younger.

Like fine lines, wrinkles will be less visible because progeline helps collagen production. Collagen improves skin elasticity, tightening it up and reducing the appearance of wrinkles.

Why Use Progeline?

There are numerous reasons to use Progeline skincare products. So, why not use progeline? Here are some excellent reasons to incorporate Progeline into your skincare regimen.

  • Encourages more collagen by supporting healthy skin
  • Increases elasticity and firmness
  • Reduces the appearance of fine lines and wrinkles
  • Promotes skin-cell regeneration
  • Tightens jowls on the jawline
  • Reduces sagging
  • Skin appears more youthful

Progeline dramatically reduces the rate at which your skin starts to look older and more tired. Instead, using pure Progeline will allow you to uncover younger, brighter, more supple-looking skin.

Progerin is scientifically linked to reducing the effects of aging. Once you incorporate this product into your routine, dullness, dryness, and loose skin will be a thing of the past.

How Does Trifluoroacetyl Tripeptide 2 Work?

Let's take a closer look at what Progeline does to your skin. We mentioned collagen above. It's a protein your body produces that makes your skin look younger.

Collagen is the most prevalent protein in your body. It affects your complexion, hair, bones, connective tissue, and nails. However, the body has difficulty producing enough collagen to support these areas as you age.

As a result, less collagen is produced overall, and another protein—progerin—begins to be synthesized in the body, blocking even more collagen production.

Progeline is a peptide (protein) that helps your body produce the collagen it needs to make your skin appear younger and fight progerin synthesis. Thus, it serves a dual purpose in combating the visible signs of aging.

Natural Ingredients Fight the Signs of Aging

Our Firming Serum Booster utilizes glycerin, a natural humectant, to draw moisture from the surrounding air and hydrate for suppleness.

Dextran is a polysaccharide that thickens, making it easy to incorporate into natural formulas. These two ingredients act as carriers.

Specific Applications of Progeline

Progeline will most benefit specific areas of your face and body. More information about these particular applications is below.

  • Restoration of elasticity—Declined collagen production dramatically affects the skin's elasticity, which is its ability to bounce back. Our skin starts to sag, droop, and loosen when we lose that ability. Progeline restores some of its elasticity and firmness.
  • Jawline (jowl area)—As people age and their skin starts to sag, one place that is the easiest to see is the lower face around the jawline. The jawbone is harder to see as the skin begins to droop down. Sometimes, it can't be seen at all once this happens. The sagging skin forms jowls on the sides of the jawbones, making them appear older than they are. Progeline can target this area by firming up the skin and tightening the jawline.
  • Neck – When the skin starts to sag on your face, that effect trickles downward. Right underneath your jawline is your neck. So naturally, the skin there also starts to droop. Then you'll also notice lines and wrinkles. Once the Progeline begins its job of tightening the skin, it helps promote increased collagen production. You will look younger again by lifting sagging areas of your neck back to their original positions.
  • Eye area—This area is notorious for making us look older than we are. Puffy bags, drooping eyelids, and crow's feet wrinkles on the sides of our eyes all visibly age us. This makes this area a prime candidate for Progeline. It helps lift the eyelid area, tighten the bags under the eyes, and reduce the appearance of crow's feet. It can also help brighten the skin around your eyes, making them look more youthful.
  • Chest – This area is one that many people focus on. It receives a lot of sun exposure because it faces up, and we often leave it uncovered during the warm months. Progeline can help smooth out the skin on the chest by promoting collagen production. It will also help regenerate new cells that are decreased by premature aging, sun exposure, and free radicals.

Progeline offers numerous benefits for your complexion. So give it a try and take your skin to the next level. You'll be happy you did.

EWG Score

The Skin Deep® ingredient hazard score, from 1 to 10, reflects known and suspected hazards linked to the ingredients. Learn more →
1-2 Low Hazard
3-6 Moderate Hazard
7-10 High Hazard

  • Glycerin Origin:
  • Water Origin:
  • Dextran Origin:
  • Trifluoroacetyl Tripeptide-2 Origin:

What is Progeline?
Progeline is a biomimetic peptide for a protein inhibitor called progerin. Progerin appears when there is a mutation in our genes due to aging. Changes in our skin due to aging cause wrinkles, sagging, loss of firmness, and less elasticity, especially around your jawline and jowls.
Why should I use Progeline?
Progeline encourages more collagen by supporting healthy skin, increases elasticity and firmness, reduces the appearance of fine lines and wrinkles, promotes skin-cell regeneration, tightens jowls on the jawline, reduces sagging, and your skin will appear more youthful.
Is Progeline Vegan?
Yes, The Firming Serum Booster with Progeline is vegan. The glycerin used is vegan.
Does this product need to be refrigerated?
We recommend placing our Firming Serum Booster with Progeline in your fridge to keep it fresh for the next time you need it.

INCI: Progeline (Glycerin (and) Water (and) Dextran (and) Trifluoroacetyl Tripeptide-2)

Recommended Usage Rate: 0.5-2%

Place in refrigerator upon arrival.

Color: Colorless

Appearance: Clear liquid

Solubility: Water-soluble

pH: 4.0-6.0

Scent: No fragrance, unscented

Storage: Store in a cool, dry place

Shelf-life: 12 months after opening

Country of Origin: Quebec, Canada

Raw Material: Plant-based

Animal Testing: Cruelty-free

GMO: Non-GMO

Vegan: Yes

CAS: 9004-54-0/64577-63-5

HS Code: 3504.00

Targets:
Fine lines and wrinkles, loss of firmness and elasticity, and promotes a youthful look.

Who will benefit: Those aging with complexions.

For a 2% concentration of Firming Serum Booster with Progeline in a 1-ounce skincare product, bulk base, or formula, add 18 drops.

Add 9 drops of Firming Serum Booster with Progeline to a 2-ounce skincare product, bulk base, or formula for a .5 % concentration.

Works With:
Compatible with other skin-firming peptides, including Pepha Tight, Relistase, Syn-Tacks, Ten's Up, and Uplevity. Add to your custom cosmetic base formula for beauty products or multifunctional skincare.

Our Firming Serum Booster with Progeline is a cosmetic active for cream, serum, or lotion making. Do not apply directly to the skin. Instead, you can add it to a base or any existing skincare product.

This will supercharge your existing product and make your skincare work a lot harder for you. Not only is it super easy to create, but it's very cost-effective—especially when compared to outrageously priced department store products.

You don't have to fork out hundreds of dollars for an expensive product. Instead, you can make your own highly concentrated formula for $20.95 for a one-ounce Hyaluronic Acid Base with 2% Progeline- even less if it's on sale! Plus, you will have enough Progeline left over to make 16 more batches! Now that's a win-win.

Applications:

  • Anti-Aging Eye Creams or Gels
  • Anti-Aging Face Serums
  • BB and CC Creams
  • Body Butters
  • Body Lotions
  • Firming Moisturizers
  • Lifting Lotions
  • Moisturizers
  • Natural Toners
  • Neck Firming Skin Care
  • Serums and more!

MSDS Sheet

Meyer Cosmetics

850061380449

Do not directly apply to your skin. Instead, add this product to a formulation at the recommended usage rate. If any irritation occurs with this product or any other skincare product, discontinue use.

For external use only, all products are cosmetic grade.

The Food and Drug Administration has not evaluated statements contained herein. This product is not intended to diagnose, treat, cure, or prevent disease. Always consult with your professional skin care provider.

California Prop 65 Statement: The following statement is made to comply with the California Safe Drinking Water and Toxic Enforcement Act of 1986. This product is not known to the State of California to cause cancer, birth defects, or other reproductive harm.

Transcript coming soon!

INGREDIENTS MATTER.

Unlock the power of Progeline and rejuvenate your skin by reducing the appearance of sagging and improving firmness, promoting a more lifted and youthful complexion.
Trifluoroacetyl Tripeptide-2 + Dextran + Glycerin

Customer Reviews

Questions & Answers

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  • I just heard of Progeline and found your website on a search for that. Just had a few questions before deciding to order. Is the Progeline product on your site pure Progeline? I’ve looked at several products on other sites and they quote glycerin, water, aloe, and all other watery type fillers. Are your products third-party tested for purity or ingredient accuracy? Can you use the Progeline by itself or does it have to be mixed in something?

    Progeline is pure from the manufacturer. We do not add anything. The ingredients list is: INCI: Progeline (Glycerin (and) Water (and) Dextran (and) Trifluoroacetyl Tripeptide-2). The manufacturer does any applicable testing. Progeline is just the anti-aging ingredient. You will need to add Progeline to an existing product or formulate your own product.

  • Can you add 18 drops of Relistase and 9 drops of Progeline to a 0.5 fl. oz to Clinically Advanced Anti-Aging Moisturizer?

    Yes, you can add any of the Firming Serum Boosters (or multiple boosters) to any anti-aging moisturizer.

  • I am thrilled to find you in my search for progeline. I have signed up to be notified....when do you expect it in? You provide a wonderful service.

    The Firming Serum Booster is back in stock!

  • Should I use Progeline once or twice a day (morning and/or night)?

    We recommend using The Firming Serum Booster with Progeline twice a day, morning and night for optimum results. However, if you only use it once a day, we recommend that you use it at night.

  • Hi - can I add 18 drops of the Progeline TT Serum Booster to Neutrogena’s Hydro Boost Hyaluronic Acid Serum (1 oz bottle)?

    Yes, you can! All of our Serum Boosters (except Copper Peptide) can be added to any of your favorite skincare products.

  • Does Progeline has expiry date? Thanks!

    The Firming Serum Booster with Progeline's expiration date is 12 months from opening.

  • I kept Progeline in the fridge instead of at room temperature. Will it still be effective as the room temperature one? Thanks!

    It is okay to place the Firming Serum Booster with Progeline in the fridge, just make sure that it is at room temperature before usage.

  • Hi, can this be mixed with your Copper Peptide product? Thanks!

    Yes, the Firming Serum Booster can be used inconjunction with Copper Peptide.

  • Can you use progeline with Tretinoin cream?

    Yes, the Firming Serum Booster with Progeline can be used in a skincare product or formula that contains Tretinoin.

Recommended Products

Frequently Asked Questions

Is Progeline peptide effective for sagging skin?
Yes. Progeline (trifluoroacetyl tripeptide-2) is a biomimetic peptide shown in laboratory and clinical research to target progerin pathways that contribute to age-related loss of firmness, which can translate to measurable improvements in sagging skin. Mechanistically, Progeline reduces progerin expression while supporting markers of collagen and extracellular matrix remodeling; topical studies and product formulations commonly use concentrations in the 1 to 2 percent range to achieve measurable effects. Users typically see improvements in skin elasticity and reduced jowl or jawline laxity with consistent daily use over multiple weeks because collagen remodeling requires time. This ingredient benefits people seeing early to moderate sagging, loss of jawline definition, or reduced skin elasticity. However, results vary with formulation strength, frequency of use, and baseline skin damage; deep tissue laxity or advanced sagging may require in-office procedures for more immediate lifting.
How long does progeline take to work?
Visible improvements with Progeline usually appear after consistent daily use for about 4 to 12 weeks. Peptide activity on progerin expression and collagen synthesis begins at the molecular level within days to weeks, but dermal collagen remodeling and measurable changes in firmness typically require two to three skin renewal cycles. You may notice temporary plumping or smoother surface texture from humectants in a formulation immediately, but sustained reduction in laxity and wrinkle depth most often becomes detectable between one and three months. Individuals with thinner, more photodamaged skin or advanced aging may need longer to see meaningful change. Effectiveness depends on topical concentration, vehicle (serum vs cream), adherence, and complementary actives such as hyaluronic acid or retinoids.
Which topical ingredient or serum produces effects most similar to Botox?
Topical products cannot reproduce Botox exactly, because Botox is an injectable neuromodulator that blocks neuromuscular signaling to produce rapid muscle relaxation. However, certain topical peptides—most notably acetyl hexapeptide (commonly called Argireline)—are formulated to modulate superficial muscle contraction and can soften expression lines in the short term. Studies and formulations report modest reductions in dynamic wrinkle depth with repeated topical use, typically requiring daily application and ongoing maintenance. Progeline works by a different mechanism, improving firmness and collagen support rather than neuromuscular relaxation, so it is better for sagging and laxity than for immediate smoothing of deep expression lines. For deep glabellar or forehead lines, injectable neuromodulators remain the clinically demonstrated option for comparable results.
Can I mix the Firming Serum Booster with Progeline into my existing skincare routine or products?
Yes, the Firming Serum Booster with Progeline is designed for easy customization, allowing you to mix it directly into your favorite serums, moisturizers, or DIY skincare bases. Its professional-grade 2% Progeline (trifluoroacetyl tripeptide-2) concentration matches the highest levels recommended by peptide manufacturers, ensuring clinical-strength anti-aging benefits without unnecessary fillers or parabens. For best results, simply add 18 drops per 1-ounce (30 ml) of serum or cream to target sagging skin, fine lines, and loss of firmness—especially on areas like the jawline, neck, and eyelids. Ingredient-savvy women seeking powerful, yet natural, collagen support will benefit most from this flexible booster. Note that while easy to incorporate, always patch test before widespread use, and those with extremely sensitive skin may wish to introduce actives gradually.
Is the Firming Serum Booster with Progeline safe for sensitive or allergy-prone skin?
Yes, the Firming Serum Booster with Progeline is formulated to be safe for most sensitive and allergy-prone skin types. It contains only pure, clinical-strength Trifluoroacetyl Tripeptide-2 (Progeline), plant-based glycerin, and dextran, with zero fillers, parabens, fragrances, or harsh preservatives—minimizing common irritants found in many department-store anti-aging products. This makes it especially appealing for educated women 35–65 looking to avoid unnecessary additives. Additionally, its vegan and cruelty-free formula is clearly labeled, and you can further customize the booster into your own unscented base or hypoallergenic moisturizer for maximum skin compatibility. While reactions are rare, anyone with a history of peptide allergies should patch-test before full use. Overall, this serum booster offers clinical-grade anti-aging benefits in a transparent, minimalist formula ideal for those who want both potency and peace of mind.