Matrixyl Synthe 6, Wrinkle Firming Filler

Anti-Aging Peptide & topical wrinkle filler Palmitoyl Tetrapeptide-38

Matrixyl® Synthe'6® or Palmitoyl Tetrapeptide 38 is an amazing new peptide for your favorite serum or moisturizer! As a result, your skin will look smoother, visibly less wrinkled, and youthful!

Sale price $29.95
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Matrixyl® Synthe'6® Serum Booster

A recommended usage rate of 2%

Our DIY Matrixyl Synthe-6 comes in a .5-ounce blue glass dropper bottle.

Matrixyl® Synthe-6 or Palmitoyl Tetrapeptide-38 is an all-new wrinkle filler. It is specifically designed to target forehead lines and crow's feet by filling in and smoothing out fine lines and wrinkles for a more youthful-looking complexion!

It is based on the tried and true results of Matrixyl 3000, which helps your skin appear more youthful. However, Matrixyl Synthe-6 takes it up a notch and helps your complexion's appearance look younger and fills in the look of wrinkles.

So boost your anti-aging product today or create your own. Our DIY collection gives you the flexibility to create an amazing product or give your favorite an extra kick.

Add this wrinkle-filling peptide to your favorite serum or moisturizer today! Your skin will look smoother, visibly less wrinkled, and more youthful!

Science-backed Visible Results

When you look in the mirror, do you see a tangle of crow's feet at the corners of your eyes? Do horizontal lines cut across your forehead, making you look older than you are? We have a solution for you!

Scientifically named palmitoyl tetrapeptide-38, Matrixyl Synthe-6 is a brand new kind of wrinkle filler specifically designed to handle the lines and wrinkles across your brow and around the corners of your eyes.

Matrixyl Synthe-6 can give you a fresher, more youthful appearance with soft, pliable, smooth skin. It fills in the lines and wrinkles on your forehead, between your eyebrows, and around the corners of your eyes. Matrixyl Synthe-6 is derived from the same ingredients in Matrixyl 3000 and taken to the next level.

Not only does it help lift and firm your skin and fills in the appearance of fine lines and wrinkles, virtually erasing them away from your face.

Age-defying DIY Skin Care

With a bottle of Matrixyl Synthe-6, you have the freedom and flexibility to boost the rejuvenating powers of almost any skincare product you like. You can also include it in your own homemade recipes for skincare too.

The latest in our DIY collection allow you to improve existing products or make your own that are specially formulated to address your particular anti-aging needs.

Are you ready to take your age-defying skincare regimen to the next level? Order a bottle of Matrixyl Synthe-6 today and add it to any skincare product for supercharged anti-aging effects.


Matrixyl Synthe-6 is an absolute powerhouse of a serum booster. It benefits your skin in many ways and can improve its appearance, giving you a more youthful and radiant look. It specifically targets:

  • Anti-aging
  • Anti-wrinkle
  • Firms and lifts
  • Crow's feet
  • Expression lines
  • Collagen promotion
  • Cellular regeneration

Adding Matrixyl Synthe-6 to your favorite serum or lotion can give you the lifting, firming, and rejuvenating results you've been longing for. Including it in your own DIY skincare products can give you the personalized age-defying effects you need for your skin type and needs.

Products that contain Matrixyl Synthe 6

If you go looking for products that contain Matrixyl Synthe-6, you'll find quite a few expensive department store brands, including:

  • City Cosmetics City Face Skin Remodeler
  • Chantal Ethocyn Oil-Free Serum
  • TwinLuxe Anti-Aging SPF 40 Moisturizer

Instead of spending a lot of money on these pre-made products, why not create a tailor-made version that gives you more lift and more wrinkle-filling action for less money?

Sample Recipes:

If you're interested in boosting the products you already have in your medicine cabinet, then pick up a bottle of Matrixyl Synthe-6 today and follow our easy step-by-step guide for adding a serum booster.

If you feel a little adventurous, try making your very own homemade skincare recipe with Matrixyl Synthe-6. Or you can follow our simple tutorial for making our Beauty Juice serum.

You'll save money and get a more effective product with visible results. Try our Matrixyl Synthe-6 serum booster today!

Using Matrixyl Synthe 6

Each Serum Booster bottle contains 300 drops. Therefore, you can make more than 16 1-ounce batches.

Add a recommended 2% concentration of Matrixyl Synthe-6 to any anti-aging, humectant, or moisturizing product. You can also use a bulk base or include it in a homemade skin care recipe.

Using a 2% concentration level ensures the best results.

Many companies use Palmitoyl Tetrapeptide 38 in their products but only add a minimal amount. As a result, the rest of the product is filled with unnecessary chemicals or cheap fillers instead of quality ingredients.

Once you've finished, place the cap firmly on the bottle of Matrixyl Synthe-6 and store it in the refrigerator. Between the chilled environment in the fridge and the glass bottle's blue tint, the contents should be protected from any dilution and stay fresh for a long time.

EWG Score

The Skin Deep® ingredient hazard score, from 1 to 10, reflects known and suspected hazards linked to the ingredients. Learn more
1-2 Low Hazard
3-6 Moderate Hazard
7-10 High Hazard

  • Hydroxypropyl cyclodextrin Origin:
  • palmitoyl tripeptide-38 Origin:
  • Glycerin Origin:
  • Water Origin:

Why should I add Matrixyl Synthe 6 to my routine?
Matrixyl Synthe 6 provides essential components that cells need to function as they did when the skin was young. As a result, a more beautiful, youthful look appears. It also provides beneficial nutrients and is safe to use on the skin. In addition, clinical studies have shown that it promotes healthy-looking complexions without irritation—good news for those with sensitive skin.
What does this product target?
Matrixyl targets some of the women's most problematic areas, including sagging, droopy skin, wrinkles around the eyes, nose, mouth, and forehead, and common ailments for mature skin with quick results!
Does this product need to be refrigerated?
We recommend placing Matrixyl Synthe 6 in your fridge to keep it fresh for the next time you need it.

INCI: Glycerin, Water, Hydroxypropyl Cyclodextrin, Palmitoyl Tripeptide-38

Recommended Usage Rate: 2%

Place in the refrigerator upon arrival.

Color: Colorless to pale yellow

Appearance: Clear liquid

Solubility: Water soluble

pH: Not available

Scent: No added fragrance, unscented

Storage: Store in a cool, dry place

Shelf-life: 12 months after opening

Country of Origin: France

Raw Material: Plant-based

Animal Testing: Cruelty-free


Vegan: Yes

CAS: 128446-35-5/1447824-23-8

HS Code: 3504.00

Palmitoyl tripeptide-38 is a wrinkle-filler obtained from a tripeptide in collagen VI. It smooths fine lines from the inside out by adding support to the dermis.

For a 2% concentration of Matrixyl Synthe-6 in a 1-ounce skincare product, bulk base, or formula, add 18 drops.

For a 2% concentration of Matrixyl Synthe-6 in a 2-ounce skincare product, bulk base, or formula, add 36 drops.

Matrixyl®-Synthe'6® is a smoothing peptide used for lotion making. It is not intended to be applied directly to the skin.

Make a quick product using a base of Hyaluronic Acid, serum, or moisturizer.


  • Anti-Aging Face Creams
  • Anti-Aging Serums
  • Day and Night Moisturizers
  • Firming Body Lotions
  • Highly Concentrated Back Bar Facial Treatments
  • Hyaluronic Facial Serums and Gels
  • Make-up Including Foundation
  • Tightening Eye Creams, Eyelash, Eyebrow Formulas, and more!

MSDS Sheet



Do not directly apply to your skin. Instead, this product should be added to a formulation at the recommended usage rate.

For external use only, all products are cosmetic grade.

The Food and Drug Administration has not evaluated the statements contained herein. This product is not intended to diagnose, treat, cure or prevent disease. Always consult with your professional skin care provider.

California Prop 65 Statement: The following statement is made to comply with the California Safe Drinking Water and Toxic Enforcement Act of 1986. This product is not known to the State of California to cause cancer, birth defects, or other reproductive harm.

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Slide 1:
Anti-Aging Solutions
Rejuvenate with Skin Smoothing Matrixyl® Synthe'6®.

Slide 2:
Video of what it is.
Boost any skincare product's effectiveness.
Simply add 18 drops of Matrixyl® Synthe'6® to a 1-ounce base, custom formula, or existing product for a 2% concentration.

Slide 3:
Highest Quality Anti-Aging Peptide for Making Skincare
Matrixyl® Synthe'6® or Palmitoyl Tetrapeptide-38 is an amazing new peptide for your favorite serum or moisturizer!

Slide 4:
Matrixyl® Synthe'6® Benefits -
Smooths and fills in the look of fine lines and wrinkles
Targets forehead lines, expression lines, and crow's feet

Slide 5:
Skin Perfection Logo
Supercharge your skin with the highest quality anti-aging peptides.

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A cutting-edge peptide blend, promotes healthy collagen, improves skin elasticity, and targets multiple signs of aging, resulting in visibly smoother, plumper, and rejuvenated skin.
Palmitoyl Tetrapeptide 38

Customer Reviews

Questions & Answers

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  • Which one is better, Matrixyl 3000 or Matrixyl Synthe-6?

    Comparing the two peptides is like comparing apples to oranges. Yes, they are both peptides that promote a youthful complexion, but they work differently. Matrixyl Synthe-6 fills in the look of wrinkles and Matrixyl 3000 regenerates skin tone. You can read more about Matrixyl 3000 vs Matrixyl Synthe-6 here:

  • Can matrixyl 6 mixed with matrixyl 3000?

    Yes, you can use Matrixyl Synthe-6 with Matrixyl 3000.