Syn-Ake Peptide Serum Booster

Ultra-Smoothing for Vertical Lines, including the 11's! You know the vertical lines between the eyebrows that make you look like you are frowning.

Syn®-Ake is an anti-aging peptide that smooths and tightens the skin, targets the forehead, vertical marionette lines, and firming facial features.

$42.99
OR
  • cruelty-free-icon
  • diy-serum-booster-icon
  • paraben-free-icon
  • recycle-reuse-icon
  • vegan-icon

Syn-Ake Serum Booster is a concentrated tripeptide booster in a 0.5 fl oz blue glass dropper bottle designed to reduce the appearance of expression lines and improve skin firmness. Its peptide sequence mimics Waglerin-1's function to relax superficial muscle contractions that contribute to the appearance of wrinkles, offering a topical alternative to injectables.

If you struggle with forehead lines, crow's feet, marionette lines, or deeper expression wrinkles, this booster helps temporarily reduce muscle microcontractions and support smoother skin texture. Add 1-5% to your favorite serum or cream following our DIY instructions, or blend into an aloe serum base for a ready-to-use product.

  • Recommended use rate 1-5% with visible smoothing reported in 7-30 days
  • 0.5 fl oz blue glass dropper bottle for stable storage of active peptides
  • Tripeptide mimic of Waglerin-1 that reduces neuromuscular signaling linked to expression lines
  • Compatible with water-based serums, creams, and DIY lotion bases for customization
  • Paraben-free formulation suitable for mixing into daytime or nightly regimens

Unlike injectables, this topical peptide offers non-invasive muscle relaxation when used consistently. Compared to low-concentration store serums, the booster is formulated for professional-strength additions so you can control active concentration. For best results, use daily and allow up to 30 days for cumulative improvement.

Backed by established peptide research and supplied in protective blue glass, this serum booster is intended for cosmetic use and formulated for stability and mixing. Follow our usage guidance and consult product documentation for formulation tips and safety recommendations.

Are you looking for the perfect wrinkle-smoothing anti-aging peptide? Experience the next generation of age-defying skincare with Syn-Ake Serum Booster, a revolutionary peptide serum inspired by the muscle-relaxing effects of viper venom but designed for your skin's safety and comfort. Syn-Ake is a tripeptide (three amino acids in a sequence) that targets expression lines, smoothing and relaxing the look of wrinkles without needles or downtime.

Syn-Ake Wrinkle Smoothing Serum Booster

Why Syn-Ake Serum Booster?

  • Instantly smooths fine lines and wrinkles —especially on the forehead, around the eyes, and around the mouth —with full results in 30 days.
  • It relaxes facial muscles to reduce the depth of expression lines, mimicking the effects of professional treatments—no injections are needed.
  • Firms and tightens sagging skin, restoring youthful elasticity and bounce.
  • Supports collagen and elastin for plumper, more resilient skin.
  • Delivers visible results in as little as one week, with continued improvements over time.

Smooth Lines with Syn-Ake

Not only does it tighten and firm skin, but it also targets the horizontal forehead lines explicitly.

Plus, the vertical "marionette lines" form around your mouth from years of smiling and frowning.

And even crow's feet, the pesky fine lines that spread from the corner of your eyes and show up when you smile.

This means you can still laugh and enjoy life without further frowning about creases. Even when you regret not wearing sun protection, life will still be okay.

Benefits of Syn-Ake

This cosmetic ingredient's significant benefit is that it inhibits the formation of mimic wrinkles. This patented technology uses the Waglerin-1 functionality, which tells your face to ignore nerve impulses that contract facial muscles.

The muscular nicotinic acetylcholine receptor (mnAChR) is turned off, blocking the ion channel. The block prevents the ion channel from consuming sodium ions (Na+). Finally, the facial muscles relax, helping your complexion look smoother and younger.

After a few days of using Syn-Ake, you'll notice those lines fading as your skin feels firmer and fuller.

For the best results, though, continue using it for 30 days. Syn-Ake's cumulative effect over a month's use is astounding.


With a bit of boost added to your serum, lotion, or cream daily, you'll look and feel noticeably younger than you have in years.

You can add Syn-Ake to your favorite skincare product to boost its performance, or include it in a DIY lotion, serum, or cream recipe. Either way, you'll notice an incredible difference.

Top 5 Solutions Syn-Ake Delivers

  • Reduces the appearance of fine lines and deep wrinkles
  • Smooths and relaxes expression lines (crow's feet, frown lines, marionette lines)
  • Firms and lifts sagging skin
  • Provides a safe, non-invasive alternative to injectables
  • Supports skin's natural collagen for long-term youthfulness

It is based on a naturally occurring phenomenon that blocks neuromuscular movements and relaxes the facial muscles that cause expression lines.

Wrinkle Smoothing & Firming

Syn®-Ake targets the area between the brows, known as the 11's, and around your mouth and chin. You know, the parenthesis is called marionette lines. Prevent (and reverse!) the effects of sagging cheeks with this fantastic firming peptide. It specifically targets:

  • Anti-aging
  • Anti-wrinkle
  • Smooth's smile and frown lines (marionette lines)
  • Skin tightening
  • Face firming

DIY Syn-Ake Serum Recipe

The process is super simple: add Syn-Ake to any existing creams, lotions, or serums you like using. For the best results, follow the instructions we give in our simple, step-by-step video tutorial to add a serum booster to any product.

With the help of a few drops of Syn-Ake, even the least expensive lotion on the market can become an overnight sensation with real rejuvenating powers.

But why stop at just adding age-defying peptides to your existing products? Instead, why not make your own lotions, creams, and serums at home? Then, you can completely tailor them to your skincare needs.

You'll love how quickly you can make them, not to mention how much money you can save!

Follow the recipe below to make a custom DIY serum in less than 5 minutes.

Syn-Ake Smoothing DIY Serum

Add one ounce of aloe serum base to a glass vessel. Then, add in the 45 drops of Syn-Ake. Next, mix for approximately 2 minutes with a hand blender. Alternatively, you can add all ingredients to an airless container. Place the lid on and shake.

Follow one of our video tutorials for making DIY serums, and check out our blog for new skincare recipes.

Don't let wrinkles write your story- rewrite it with Syn-Ake Serum Booster. Add it to your daily routine and discover visibly smoother, firmer, and more radiant skin. Try Syn-Ake today and see why so many call it their secret for ageless beauty!

EWG Score

The Skin Deep® ingredient hazard score, from 1 to 10, reflects known and suspected hazards linked to the ingredients. Learn more →
1-2 Low Hazard
3-6 Moderate Hazard
7-10 High Hazard

  • Glycerin Origin:
  • Water Origin:
  • Dipeptide Diaminobutyroyl Benzylamide Diacetate Origin:

How does Syn-Ake work?
Syn-Ake is a tripeptide that combines three amino acids in a sequence. It is based on a naturally occurring phenomenon that blocks neuromuscular movements and relaxes the facial muscles that cause expression lines.
Does this product need to be refrigerated?
We recommend placing Syn-Ake in your fridge to keep it fresh for the next time you need it.

INCI: Glycerin (and) Water (and) Dipeptide Diaminobutyroyl Benzylamide Diacetate

Recommended Usage Rate: 1-5%

Place in the refrigerator upon arrival.

Color: Colorless

Appearance: Clear liquid

Solubility: Water-soluble

pH: 4.5-5.5

Scent: Slight, natural scent

Storage: Store in a cool, dry place

Shelf-life: 12 months after opening

Country of Origin: France

Raw Material: Plant-based

Animal Testing: Cruelty-free

GMO: Non-GMO

Vegan: Yes

CAS: 56-81-5

HS Code: 3504.00

Dipeptide Diaminobutyroyl Benzylamide Diacetate is a wrinkle-smoothing peptide that inhibits muscle contractions.

Add 45 drops to a 1-ounce skincare product, bulk base, or formula for a 5% concentration of Syn-Ake.

Add 18 drops of Syn-Ake to a 2-ounce skincare product, bulk base, or formula for a 1% concentration.

Syn-Ake is an anti-wrinkle cosmetic active used for formulating and is not intended for direct skin use. However, if you have sensitive skin, perform a patch test with this and all other ingredients.

Add enough drops of Syn-Ake to your favorite anti-aging cream or skincare product to achieve a 1-5% concentration. You can also use your own recipe. This will be enough to firm and tone your skin, significantly diminishing smile and frown lines as you continue using it.

Once you've added the peptide to your product, shake or stir. Then, put the cap back on the serum booster bottle and store it in the refrigerator. You do not need to refrigerate your finished formula. In just a few days, you will start seeing results.

Syn-ake also has a cumulative face-firming effect. Therefore, you should use it for at least 30 days until you see full firming results.

The bottle's blue tint will protect this potent peptide from breaking down due to light exposure, and the chilled environment of the refrigerator will keep it from losing strength.

When you need to use it next, it will be just as fresh and active as when you first opened it.

Syn-Ake is widely utilized in the skincare and cosmetics industry to enhance smoothing and skin-firming capabilities.

These designers and department store products can cost between $30 and $130 (or even more) for a one-ounce bottle of serum. Among other products, you'll find these, all of which fall within that price range:

NuFace Smoother (S2) Peptide Serum
Dr. MJ Syn-Ake Venom Lifting Cream
Nutri Syn-Ake Peptide Complex
Why pay so much when you can purchase a bottle of pure Syn-Ake that you can then add to any existing or DIY serum, lotion, or cream? Thus making skincare affordable and costing less than department store brands.

Plus, you get the best results possible for your skin when choosing to enhance your skincare products with products like Syn-Ake from our DIY Collection.

SYN, SYN-AKE, REGU, and REGU-AGE are trademarks of DSM.

Applications:

  • Anti-Aging Facial Serums
  • Body Butters
  • Day and Night Firming Moisturizers
  • Eye Gels and Creams
  • Hyaluronic Face Serums
  • Firming Lotions
  • Smoothing Syn-Ake Sheet Mask with Viper Venom
  • Wrinkle Patches, Eye Patches, and more!

MSDS Sheet

DSM Nutritional Products AG

850061380500

Do not directly apply to your skin. Instead, this product should be added to a formulation at the recommended usage rate.

For external use only, all products are cosmetic grade.

The Food and Drug Administration has not evaluated statements contained herein. This product is not intended to diagnose, treat, cure, or prevent disease. Always consult with your professional skin care provider.

California Prop 65 Statement: The following statement is made to comply with the California Safe Drinking Water and Toxic Enforcement Act of 1986. This product is not known to the State of California to cause cancer, birth defects, or other reproductive harm.

Intro music

Slide 1:
Anti-Aging Solutions
Rejuvenate with Smoothing and Firming Syn®-Ake

Slide 2:
Video of what it is.
Boost any skincare product's effectiveness.
Simply add 45 drops of Syn®-Ake to a 1-ounce base, custom formula, or existing product for a 5% concentration.

Slide 3:
Highest Quality Anti-Aging Peptide for Making Skincare
Syn®-Ake or Dipeptide Diaminobutyroyl Benzylamide Diacetate, an anti-aging peptide that smooths and tightens the skin, targets the forehead, and vertical marionette lines, firming facial features.

Slide 4:
Syn®-Ake Benefits -
Anti-aging
Anti-wrinkle
Smile and frown lines (marionette lines)
Skin tightening
Firms and lifts

Slide 5:
Skin Perfection Logo
Supercharge your skin with the highest quality anti-aging peptides.

Outro music

INGREDIENTS MATTER.

Inspired by wrinkle-smoothing treatments that smooth frown lines, the 11's, and vertical wrinkles. Syn-Ake minimizes the appearance of expression lines and wrinkles, and provides a smoother and more relaxed complexion.
Dipeptide

Customer Reviews

Questions & Answers

Have a Question?

Ask a Question

  • Can Syn-Ake be used all over the face and neck? Or, is it a target peptide to be used only on certain areas of the face?

    Syn-Ake can be used in an all-over face and neck serum or used as a spot treatment. It smooths out and relaxes lines

  • Is this the best peptide for forehead wrinkles?

    Syn-Ake is great for smoothing forehead wrinkles. It also works on vertical wrinkles including the 11's. We recommend using it with Snap 8, Syn-Coll and Uplevity or another tightener for a complete blend to target forehead wrinkles.

  • Can I add any of your boosters i.e. Syn-Ake, Matrixyl 3000, Relistase, and Juveleven to a pure aloe Vera base (I have my own plants)? And do you have a recipe I can use? I plan on adding some of your Hyaluronic Acid to this super serum.

    Yes, you can add any of our Serum Boosters, including, but not limited to, Syn-Ake, Matrixyl 3000, Relistase, and Juveleven Peptide to an Aloe Vera Base. Hyaluronic Acid would also make a great addition. You can find our recipes in the formulary.

  • I mixed this peptide with a serum. How long must I wait until I apply an oil to my face and sunscreen?

    As soon as it is dry, you can apply an oil. Generally, it should only take a few seconds to dry.

  • I purchased the syn-ake and i have been using for over 30 days. I have no tightening at all and the lines on the forehead are the same. I do not see a difference at all

    Make sure you are using a 5% concentration of Syn-Ake, two times a day. Using it with Pepha Tight (tightener), Syn Coll (collagen boost), Snap-8 (anti-wrinkle peptide) will boost its effectiveness.

  • Approximately how many drops are in the bottle? I need to know how far 1 bottle goes. Thank You

    There are approximately 300 drops in one .5 ounce bottle.

  • Why is Syn-Ake so effective?

    Syn-Ake is made up of peptides that focus on the immediate smoothing and lasting relaxing of the mimic wrinkles, the vertical wrinkles bewtween the brows. They are also called the 11's or frown lines. 

    Syn-Ake can also work on smoothing other areas of the face, such as around the mouth and above the upper lip.

Recommended Products

Frequently Asked Questions

What serum is closest to Botox?
No topical serum can exactly replicate Botox injections, but Syn-Ake Serum Booster is formulated as the closest non-invasive alternative because it mimics the muscle-relaxing mechanism of neurotoxin treatments. Specifically, Syn-Ake is a tripeptide based on Waglerin-1 functionality that targets the muscular nicotinic acetylcholine receptor (mnAChR) to reduce muscle contraction-driven expression lines; the product is intended for use at 1–5% and is supplied in a .5 fl. oz. dropper bottle for precise dosing. It delivers visible smoothing in as little as one week with cumulative improvement over 30 days when used consistently, making it a practical option for people who want reduced dynamic lines without injections. Best suited for educated, ingredient-savvy users seeking a topical, DIY-friendly alternative for forehead lines, crow’s feet, and marionette lines. Limitation: Syn-Ake can soften expression lines but does not provide the same depth or duration of effect as medically administered injectables, so consult a clinician for severe dynamic wrinkles.
What is a peptide booster serum?
A peptide booster serum is a concentrated active intended to raise the peptide level in your skincare routine rather than replace your whole serum; it’s designed to be added in small percentages to creams, lotions, or a base. These boosters contain targeted peptides such as Syn-Ake (a tripeptide) or other clinical peptides that support muscle-relaxing effects, collagen signaling, and skin-firming pathways; recommended usage rates vary by peptide but Syn-Ake is commonly used at 1–5% and our DIY recipe uses 45 drops per 1 ounce of aloe serum base as a practical guideline. Peptide boosters are valuable because they deliver measurable actives without fillers, let you customize concentrations, and can be combined with hydrating bases like hyaluronic-acid serums for better penetration. Best for ingredient-savvy women seeking professional-strength, targeted anti-aging benefits. Limitation: boosters must be diluted correctly and patch tested; avoid simultaneous use with incompatible high-strength actives unless guided by a skincare professional.
How do I add Syn-Ake Serum Booster to my current skincare routine?
Yes, you can safely add Syn-Ake Serum Booster to an existing serum, cream, or DIY base by following recommended dilution and layering practices. Use Syn-Ake at 1–5% concentration for topical applications; for example, our DIY Smoothing Serum recommends 45 drops of Syn-Ake per 1 ounce of aloe serum base, blended thoroughly and stored in a closed container. Apply the mixture to clean skin where expression lines form, typically after cleansing and hydrating serums and before heavier creams or oils, and start with nightly use to assess tolerance. Who benefits most: mature, ingredient-literate users wanting to boost forehead, eye, and mouth lines without injections and those who prefer customizing product strength. Limitation: perform a patch test, avoid mucous membranes and broken skin, and consult a clinician if you use prescription actives, are pregnant, or have neuromuscular conditions.
Is Syn-Ake Serum Booster suitable for sensitive skin or allergy-prone users?
Yes, Syn-Ake Serum Booster is generally well-tolerated by sensitive and allergy-prone skin due to its minimalist, paraben-free, and filler-free formula. The serum features a high concentration of the active peptide Syn-Ake, clinically shown to smooth expression lines without causing irritation commonly associated with invasive treatments or harsher anti-aging ingredients. Our preparation contains no added fragrances, dyes, or common allergens, which makes it especially appealing to ingredient-conscious customers who want professional results without compromising skin health. Educated shoppers seeking to minimize potential reactions while maximizing wrinkle-fighting power will appreciate its transparent, clean-label formulation. However, as with any powerful anti-aging active, we recommend patch-testing before first use, especially if you have a history of skin sensitivities or allergies, or consult your dermatologist for personalized advice.
How is Syn-Ake Serum Booster different from other anti-aging peptides like Matrixyl or Argireline?
Syn-Ake Serum Booster is uniquely formulated to specifically target dynamic expression lines by mimicking the wrinkle-relaxing effects of viper venom without any risk, making it distinctly different from traditional anti-aging peptides like Matrixyl or Argireline. While Matrixyl focuses on stimulating collagen production for overall wrinkle reduction and Argireline helps inhibit muscle contractions similar to mild injectables, Syn-Ake's patented tripeptide technology directly blocks the muscular nicotinic acetylcholine receptor (mnAChR), reducing the depth of forehead and crow’s feet wrinkles in as little as 7 days—with full visible results in 30 days at concentrations up to 5%. This targeted relaxation makes Syn-Ake especially beneficial for women who have stubborn, deep-set expression lines but want a non-invasive, customizable booster that can be added to any serum or cream without fillers or parabens. Those seeking an alternative to professional injectables or a highly focused solution for motion wrinkles will benefit most, though users with only static lines may see better results from collagen-stimulating peptides.