Ultra-Smoothing for Vertical Lines, including the 11's! You know the vertical lines between the eyebrows that make you look like you are frowning.

Syn®-Ake is an anti-aging peptide that smooths and tightens the skin, targets the forehead, vertical marionette lines, and firming facial features.

Sale price $34.95
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Syn-Ake Serum Booster

The recommended usage rate is 1-5%.

Our Syn-ake comes in a .5 FL. Oz. Blue Glass Dropper Bottle.

Are you looking for the perfect wrinkle-smoothing anti-aging peptide? Syn-Ake's scientific name is a real mouthful, di-peptide diamino butyryl benzyl-amide di-acetate.

It may be hard to pronounce all those syllables, but it's not hard to love the amazing results of using this incredible anti-aging peptide.

Syn-Ake | Wrinkle Smoothing Cream

It is a tripeptide that combines three amino acids in a sequence.

It is based on a naturally occurring phenomenon that blocks neuromuscular movements and relaxes the facial muscles that cause expression lines.

Smooth Lines with Syn-Ake

Not only does it tighten and firm skin, but it specifically targets the horizontal expression lines across your forehead.

Plus, the vertical "marionette lines" form around your mouth from years of smiling and frowning.

And even crow's feet, the pesky fine lines that spread from the corner of your eyes and show up when you smile.

This means you can still laugh and enjoy life without further frowning about creases. And the times you regret not wearing sun protection, life will still be okay.

Benefits of Syn-Ake

This cosmetic ingredient's terrific benefit is that it inhibits mimic wrinkles. This patented technology uses the Waglerin-1 functionality, which tells your face to ignore nerve impulses that contract facial muscles.

The muscular nicotinic acetylcholine receptor (mnAChR) is turned off, blocking the ion channel. The block prevents the ion channel from consuming sodium ions (Na+). Finally, facial muscles relax, helping your complexion become smooth and younger-looking.

After a few days of using Syn-Ake, you'll notice those lines fading away as your skin feels firmer and fuller.

For the best results, though, continue using it for 30 days. Syn-Ake's cumulative effect over a month's use is astounding.

With a bit of boost added to your serum, lotion, or cream daily, you'll look and feel noticeably younger than you have in years.

You can add Syn-Ake to your favorite skincare product to boost performance or include it in a DIY homemade lotion, serum, or cream recipe. Either way, you'll notice an incredible difference.

Order your bottle of Syn-Ake today and find out for yourself how effective it truly is.

Syn®-Ake targets the area in between the brows, known as the 11's and around your mouth and chin. You know, the parenthesis is called marionette lines. Prevent (and reverse!) the effects of sagging cheeks with this fantastic firming peptide. It specifically targets:

  • Anti-aging
  • Anti-wrinkle
  • Smooth's smile and frown lines (marionette lines)
  • Skin tightening
  • Face firming

DIY Syn-Ake Serum Recipe

The process is super simple if you add Syn-Ake to any existing creams, lotions, or serums you like using. For the best results, follow the instructions we give in our simple, step-by-step video tutorial to add a serum booster to any product.

With the help of a few drops of Syn-Ake, even the least expensive lotion on the market can become an overnight sensation with real rejuvenating powers.

But why stop at just adding age-defying peptides to your existing products? Instead, why not make your own lotions, creams, and serums at home? Then, you can completely tailor them to your skincare needs.

You'll love how quickly you can make them, not to mention how much money you can save!

Follow the recipe below to learn how to make a custom DIY serum in less than 5 minutes.

Syn-Ake Smoothing DIY Serum

Add one ounce of aloe serum base to a glass vessel. Then, add in the 45 drops of Syn-Ake. Next, mix for approximately 2 minutes with a hand blender. Alternatively, you can add all ingredients to an airless container. Place the lid on and shake. 

Follow one of our video tutorials for making DIY serums, and check out our blog for new skincare recipes.

Order your Syn-Ake today and start looking and feeling your best—at a fraction of the price of expensive designer skincare products!

EWG Score

The Skin Deep® ingredient hazard score, from 1 to 10, reflects known and suspected hazards linked to the ingredients. Learn more
1-2 Low Hazard
3-6 Moderate Hazard
7-10 High Hazard

  • Glycerin Origin:
  • Water Origin:
  • Dipeptide Diaminobutyroyl Benzylamide Diacetate Origin:

How does Syn-Ake work?
Syn-Ake is a tripeptide that combines three amino acids in a sequence. It is based on a naturally occurring phenomenon that blocks neuromuscular movements and relaxes the facial muscles that cause expression lines.
Does this product need to be refrigerated?
We recommend placing Syn-Ake in your fridge to keep it fresh for the next time you need it.

INCI: Glycerin (and) Water (and) Dipeptide Diaminobutyroyl Benzylamide Diacetate

Recommended Usage Rate: 1-5%

Place in the refrigerator upon arrival.

Color: Colorless

Appearance: Clear liquid

Solubility: Water-soluble

pH: 4.5-5.5

Scent: Slight, natural scent

Storage: Store in a cool, dry place

Shelf-life: 12 months after opening

Country of Origin: France

Raw Material: Plant-based

Animal Testing: Cruelty-free


Vegan: Yes

CAS: 56-81-5

HS Code: 3504.00

Dipeptide Diaminobutyroyl Benzylamide Diacetate is a wrinkle-smoothing peptide that inhibits muscle contractions.

For a 5% concentration of Syn-Ake in a 1-ounce skincare product, bulk base, or formula, add 45 drops.

For a 1% concentration of Syn-Ake in a 2-ounce skincare product, bulk base, or formula, add 18 drops.

Syn-Ake is an anti-wrinkle cosmetic active used for formulating and is not intended for direct use on the skin. However, if you have sensitive skin, perform a patch test with this and all other ingredients.

Add enough drops of Syn-Ake to your favorite anti-aging cream or skincare product to achieve a 1-5% concentration. You can also use your own recipe. This will be just enough to firm and tone your skin, significantly diminishing smile and frown lines as you continue to use it.

Once you've finished adding the peptide to your product, shake or stir, then put the cap back on the bottle and put it in the refrigerator for storage. In just a few days, you will start seeing results.

Syn-ake also has a cumulative face-firming effect. Therefore, you will want to use it for 30 days until you see full firming results.

The bottle's blue tint will protect this potent peptide from breaking down due to light exposure, and the chilled environment of the refrigerator will keep it from losing strength.

When you need to use it next, it will be just as fresh and active as when you first opened it.

Syn-Ake is widely utilized in the skincare and cosmetics industry to enhance smoothing and skin-firming capabilities.

These designers and department store products can cost between $30 and $130 (or even more) for a one-ounce bottle of serum. Among other products, you'll find these, all of which fall within that price range:

NuFace Smoother (S2) Peptide Serum
Dr. MJ Syn-Ake Venom Lifting Cream
Nutri Syn-Ake Peptide Complex
Why pay so much when you can purchase a bottle of pure Syn-Ake that you can then add to any existing or DIY serum, lotion, or cream? Thus, making skincare affordable and costing less than department store brands.

Plus, you get the best results possible for your skin when choosing to enhance your skincare products with products like Syn-Ake from our DIY Collection.


  • Anti-Aging Facial Serums
  • Body Butters
  • Day and Night Firming Moisturizers
  • Eye Gels and Creams
  • Hyaluronic Face Serums
  • Firming Lotions
  • Smoothing Syn-Ake Sheet Mask with Viper Venom
  • Wrinkle Patches, Eye Patches, and more!

MSDS Sheet



Do not directly apply to your skin. Instead, this product should be added to a formulation at the recommended usage rate.

For external use only, all products are cosmetic grade.

The Food and Drug Administration has not evaluated statements contained herein. This product is not intended to diagnose, treat, cure or prevent disease. Always consult with your professional skin care provider.

California Prop 65 Statement: The following statement is made to comply with the California Safe Drinking Water and Toxic Enforcement Act of 1986. This product is not known to the State of California to cause cancer, birth defects, or other reproductive harm.

Intro music

Slide 1:
Anti-Aging Solutions
Rejuvenate with Smoothing and Firming Syn®-Ake

Slide 2:
Video of what it is.
Boost any skincare product's effectiveness.
Simply add 45 drops of Syn®-Ake to a 1-ounce base, custom formula, or existing product for a 5% concentration.

Slide 3:
Highest Quality Anti-Aging Peptide for Making Skincare
Syn®-Ake or Dipeptide Diaminobutyroyl Benzylamide Diacetate, an anti-aging peptide that smooths and tightens the skin, targets the forehead, and vertical marionette lines, firming facial features.

Slide 4:
Syn®-Ake Benefits -
Smile and frown lines (marionette lines)
Skin tightening
Firms and lifts

Slide 5:
Skin Perfection Logo
Supercharge your skin with the highest quality anti-aging peptides.

Outro music


Inspired by wrinkle-smoothing treatments that smooth frown lines, the 11's, and vertical wrinkles. Syn-Ake minimizes the appearance of expression lines and wrinkles, and provides a smoother and more relaxed complexion.

Customer Reviews

Questions & Answers

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  • Can Syn-Ake be used all over the face and neck? Or, is it a target peptide to be used only on certain areas of the face?

    Syn-Ake can be used in an all-over face and neck serum or used as a spot treatment. It smooths out and relaxes lines

  • Is this the best peptide for forehead wrinkles?

    Syn-Ake is great for smoothing forehead wrinkles. It also works on vertical wrinkles including the 11's. We recommend using it with Snap 8, Syn-Coll and Uplevity or another tightener for a complete blend to target forehead wrinkles.

  • Can I add any of your boosters i.e. Syn-Ake, Matrixyl 3000, Relistase, and Juveleven to a pure aloe Vera base (I have my own plants)? And do you have a recipe I can use? I plan on adding some of your Hyaluronic Acid to this super serum.

    Yes, you can add any of our Serum Boosters, including, but not limited to, Syn-Ake, Matrixyl 3000, Relistase, and Juveleven Peptide to an Aloe Vera Base. Hyaluronic Acid would also make a great addition. You can find our recipes in the formulary.

  • I mixed this peptide with a serum. How long must I wait until I apply an oil to my face and sunscreen?

    As soon as it is dry, you can apply an oil. Generally, it should only take a few seconds to dry.

  • I purchased the syn-ake and i have been using for over 30 days. I have no tightening at all and the lines on the forehead are the same. I do not see a difference at all

    Make sure you are using a 5% concentration of Syn-Ake, two times a day. Using it with Pepha Tight (tightener), Syn Coll (collagen boost), Snap-8 (anti-wrinkle peptide) will boost its effectiveness.

  • Approximately how many drops are in the bottle? I need to know how far 1 bottle goes. Thank You

    There are approximately 300 drops in one .5 ounce bottle.

  • Why is Syn-Ake so effective?

    Syn-Ake is made up of peptides that focus on the immediate smoothing and lasting relaxing of the mimic wrinkles, the vertical wrinkles bewtween the brows. They are also called the 11's or frown lines. 

    Syn-Ake can also work on smoothing other areas of the face, such as around the mouth and above the upper lip.