Matrixyl Synthe 6™

Showing 4 of 4 products

Matrixyl Synthe 6 Helps You Look More Youthful

EWG Rating

Matrixyl Synthe-6 Skin Deep Safety ReviewScientific Name: {Palmitoyl Tetrapeptide 38}
Common Name: {Matrixyl 6000, Matrixyl S-6}

A powerful new version of Matrixyl 3000 is even more effective at reducing the signs of aging. What began as Matrixyl 1999 (a single peptide) became Matrixyl 3000 (a double peptide).

With even more peptides and significant skin benefits, we have Matrixyl Synthe 6, with four peptides referred to as S-6 or 6000. The result of years of study and trials brings the best anti-aging ingredients to the skincare world.

Matrixyl Synthe-6 (Palmitoyl Tetrapeptide-38)

The ever-evolving skincare landscape introduces us to gems that promise youthful radiance, and Matrixyl Synthe-6 stands out among them. This powerful peptide, also known as Palmitoyl Tetrapeptide-38, is a derivative designed to boost the production of six major components of the skin matrix. Think of it as the dynamo behind the scenes, orchestrating a symphony of skin rejuvenation.

Ideal for those showing early signs of aging, Matrixyl Synthe-6 works by filling in wrinkles from the inside out—a process known as topical wrinkle filling. The beauty community's rave reviews come as no surprise; the peptide's efficacy is backed by scientific data, and it's loved for rendering smoother, plumper, and youthful skin without invasive treatments.

Beauty aficionados and professionals alike have lauded Matrixyl Synthe-6 for its innovative approach to age-defying skincare, making it a coveted ingredient in the world of cosmetics.

Youthful Boost From Peptides

This ingredient contains Palmitoyl Tetrapeptide-38, which is better at targeting problem areas than the previous versions. Matrixyl targets some of the women's most problematic areas, including sagging, droopy skin, wrinkles around the eyes, nose, mouth, and forehead, and common ailments for mature skin. Matrixyl Synthe 6 Helps your Face Look and Act More Youthful

Unlike other anti-aging solutions, you will not have to wait to see your investment results. Instead, Matrixyl Synthe 6 works as soon as you apply it, smoothing the appearance of wrinkles.

Lines around the mouth look smoother and more filled. In addition, those worry lines on the forehead appear less noticeable, and the appearance of the crow's feet around the eyes is significantly diminished from the first application. This is what sets this ingredient apart from other components.

Supple Complexions & Collagen

As it begins to smooth the appearance of wrinkles, the peptides in Matrixyl Synthe 6 also signal the skin to produce more cells that keep it looking young and healthy. Unfortunately, as we age, collagen and elastin begin to break down in the skin, which causes a sagging, wrinkled complexion.

The support structures and connective tissue also begin to wear away, exacerbating the signs of aging. Matrixyl Synthe 6 peptides improve the skin's ability to produce the collagen it needs to look young and whole again. It tells the skin that it is once again time to start producing collagen and hyaluronic acid.

Matrixyl Synthe 6 supports structures, making the cells stronger and more elastic. In addition, the hydrating hyaluronic acid fills the cells, making a face's volume look fuller and younger. Unfortunately, mature complexions often suffer from significant dehydration, making them look even more sunken and sallow than they would otherwise.

Synthe 6 provides essential components that cells need to function as they did when the skin was young. As a result, a more beautiful, youthful look appears.

Homemade DIY Wrinkle Filling Serums

Matrixyl Synthe 6 provides beneficial nutrients and is safe to use on the skin. In addition, clinical studies have shown that it promotes healthy-looking complexions without irritation—good news for those with sensitive skin. Use a base of Hyaluronic Acid and S-6 to create a custom-tailored serum without fillers or fragrances.

Custom-Tailored Wrinkle-Filling Skincare Serum with Matrixyl Synthe-6

This potent serum combines the proven power of Matrixyl Synthe-6 with a carefully curated selection of peptides to target wrinkles and smooth the skin. Remember, when working with potent ingredients, it's essential to ensure proper ratios and compatibility. Always do a patch test before applying any new product to your entire face.


    • Matrixyl Synthe-6 (Palmitoyl Tetrapeptide-38): 3% Target: Deep wrinkles and fine lines
    • Argireline (Acetyl Hexapeptide-8): 10% Expression lines, especially around the eyes and forehead
    • Snap-8 (Acetyl Octapeptide-3): 10% Target: Deep wrinkles and expression lines
    • Syn-Ake (Dipeptide Diaminobutyroyl Benzylamide Diacetate): 4% Target: Expression lines and crow’s feet
    • Hyaluronic Acid (for hydration and plumping): 2%
    • Glycerin: 5% Hydration agent to enhance skin moisture
    • Aloe Vera Gel: 10% Soothes and provides a lightweight base
    • Distilled Water: Q.S (Quantity Sufficient) to make 100%
    • Leucidal SF Complete: 4%


    1. Start by sanitizing all tools, containers, and your workspace.
    2. In a clean mixing bowl, add the distilled water.
    3. Slowly sprinkle in the hyaluronic acid while stirring to avoid clumping. Allow it to hydrate for about 30 minutes.
    4. Once the hyaluronic acid has hydrated, add in the Matrixyl Synthe-6, Argireline, Snap-8, and Syn-Ake. Stir gently until all ingredients are dissolved.
    5. Add in the glycerin and mix well.
    6. Slowly incorporate the Aloe Vera Gel, ensuring a smooth blend.
    7. Finally, add the preservative and mix until homogenous.
    8. Transfer the mixture to a clean, sanitized serum bottle using a funnel.
    9. Seal the bottle, label it, and store it in a cool, dry place.

    Matrixyl Synthe-6 vs. Epidermal Growth Factors

    Epidermal Growth Factors promote skin regeneration. They are the creme de la creme when it comes to anti-aging ingredients. But they also come at a high cost. Using a matrikine-like peptide can also enhance dermal rejuvenation. In cosmetic products, matrikines contain tiny molecules that enhance skin penetration. Peptides can promise growth factor-like activities using products containing growth factors, cytokines, or matrikines.

    Matrixyl Synthe' 6 Reviews

    Matrixyl is the best. I prefer the 3000 version over the Synthe-6, but I generally use both to make a serum.

    I can't get enough peptides! They all sound so good. I use 5 or 6 every day and see a huge difference. I have wanted to try Matrixyl Synthe-6 for a while now. So I am adding it to Syn-Tacks, Syn-Ake, and a few others.

    Benefits of Matrixyl Synthe-6

    Supports Collagen: It notably boosts collagen types I, III, and IV, reviving the skin's firmness.

    Enhances Skin Elasticity: By promoting two proteins, laminin V and fibronectin, it makes the skin supple.

    Optimizes Cellular Activity: By rejuvenating the skin's scaffolding, it revamps and renews skin structure.

    Reduces Wrinkle Depth: Noticeable effects on forehead lines and crow's feet due to its filling properties.

    Improves Overall Skin Texture: Offers a holistic approach by also targeting matrix molecules like hyaluronic acid, ensuring deep hydration and a fuller appearance.


    Lintner, K., & Peschard, O. (2012). Biologically active peptides: from a laboratory bench curiosity to a functional skin care product. International journal of cosmetic science, 34(3), 278-287. This study highlights the science behind Matrixyl Synthe-6 and its significance in cosmetic applications, demonstrating its ability to rejuvenate the skin's structural matrix.


    About the Author
    Kari Thomas wrote this article.