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    Argireline, Acetyl Hexapeptide 8

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The number 1 wrinkle remedy

Argireline is the Most Trusted Anti-Aging Peptide Today

EWG Rating
Argireline, The Most Trusted Anti-Aging Peptide Today

Scientific Name: {Acetyl Hexapeptide-8}
Common Name: {Argireline® peptide, Argireline, Natural Botox® Alternative}

Argireline is the most trusted anti-aging peptide.

It is one of the most popular, widely used, and reputable anti-wrinkle peptides used in the skincare industry.

A hexapeptide is a strand of six amino acids. The amino acids help the expression line muscles that we use daily to relax. The SNARE Complex accomplishes this. When our facial muscles are relaxed, they often don't contract, promoting a reduction in the appearance of wrinkles.

Botox® paralyzes the muscle, so it is unable to contract. Acetyl Hexapeptide-8 is one of the best alternatives to wrinkle injections. It targets the most used expression lines, such as crow's feet and brow furrows. It reduces the appearance of fine lines and wrinkles. Try applying a few drops forehead and around the eyes.

So if you want to stay away from needles, this is one anti-aging peptide to check out! It is recommended to use a 10% concentration morning and night.

What is Argireline?

It is an anti-aging peptide. A peptide is a protein that is the building block of our skin.

Snare Complex to Relax Wrinkles What is a peptide? It is a strand of amino acids. The type of peptide depends on the beginning; for example, a tripeptide is a strand of three amino acids. Thus, Hexa means 6, Penta means 5, etc.

At one time, it was called Acetyl Hexapeptide-3. However, it is now referred to as Acetyl Hexapeptide-8. So if you see it referenced with a 3, then the article or label is likely old and not updated.

Injections and Facial Muscles

Women widely use it as an alternative to Botox®. As it is often referred to as "botox in a bottle." However, unlike Botox®, it does not require expensive injections and has fewer and less extreme side effects.

Specifically, a hexapeptide, which means it has six amino acids linked together. Amino acids are proteins, and they are essential for all life.

Its scientific name is Acetyl Hexapeptide-8. When it first came onto the market, it was called Acetyl Hexapeptide-3. This has caused some confusion in the marketplace. If you see a product using "Acetyl Hexapeptide-3," it is because they have not updated labels or website information. It is used to replace more extreme anti-aging measures because it is designed to perform the same functions.

Topical Treatments for Wrinkles

When applied topically, it works against the Neurotransmitter. Neurotransmitters signal muscles in specific areas, relaxing the muscle. Then, it softens the appearance of wrinkles above that muscle.

The muscles in our faces allow us to express emotions. We may not even realize we're contracting them. For example, if you squint a lot, you may start to get crow's feet around your eyes. If you stop squinting, the wrinkles will disappear. However, as we age, these muscles can become permanently contracted, and the lines above them will become permanent too. These lines are most commonly seen around the eyes, mouth, and forehead, which are the areas of the face that move the most. They may start small but can become deep and pronounced over time.
neurotransmitters synapse for skin-smoothing properties

Expression Lines

These are most commonly called "expression lines" and occur around the eyes, around the mouth, and on the forehead, our most "active" facial areas. These lines may start small, but as time goes on, they become thick and pronounced.

Argireline penetrates the skin and, just like Botox®, partially paralyzes the muscles beneath the skin to not contract. As a result, we see the look of these lines and wrinkles become relaxed on the skin's surface.

Neurotransmitters target dynamic wrinkles (repeated muscle movement—think squinting and contracting, like crows' feet around the eyes or the "11s" in between your brows). The only way to get instant results to eliminate the wrinkle entirely is to use an injectable neurotoxin link Botox, Dysport, or Jeuveau. Paralyzing the muscle prevents this movement, and viola—wrinkles are gone. Try Argireline if you prefer a more natural approach and don't want to go under the needle. It is a topical peptide that fights the appearance of wrinkles. 

To tackle multiple signs of aging, combined with a peptide that lifts and firms or boosts collagen. For example, Argireline can improve areas on the face prone to developing dynamic folds, like laugh lines.

Clinical studies have shown that Argireline can be handy at diminishing the appearance of these lines and wrinkles, which are often the most telling signs of age. But it can work even better when used with other ingredients.

Visible Results of Acetyl Hexapeptide-8

Studies have shown that women using a 10% solution of Argireline saw up to a 30% reduction in the depth of their most problematic wrinkles. 

The study is why you have seen Dr. Oz raving about Argireline. On TV, Dr. Oz shares about topical and effective anti-aging products available. The best part is that they don't cost a fortune and are not loaded with a million chemicals.

Argireline is an anti-aging ingredient that is backed up by clinical studies and is one of the best tried and true anti-aging ingredients among women today.

Clinical studies have shown that Argireline Peptide improves the look of wrinkles, including in areas prone to developing more prominent wrinkles, and improves dynamic folds.

It works on forehead wrinkles, laugh lines, and eyebrow furrows. Plus, it is excellent for crow's feet around the eyes, quickly taking years off your appearance. Finally, it's just an all-around great ingredient.

Acetyl Hexapeptide-8 or Argireline Side Effects

There is a lot of hype on the internet. One primary concern is if there are any side effects of using Argireline. For example, some men and women have read that Argireline will cause sagging skin and make their faces sag.

Others are concerned about the fact that it inhibits muscle contraction. When face muscles are tight and rigid, they can cause the face to wrinkle up. Think about the eyebrow furrows; they are one or two muscles that are scrunched up and tight.

Squinting can create fine lines, creases, wrinkles, and ridges. Or think about the crow's feet around the eyes. When you are in the sun, your eyes squint. The more you squint, the sooner you begin seeing crow's feet around the eyes. It's the repetitive muscle contractions that cause creases to form. When your facial muscles are relaxed, your face is smoother and less wrinkled.

Argireline is as safe as any other anti-aging product. It is much safer to use that Botox®, which can easily cause toxicity in the face and has undesirable side effects. Such as droopy eyelids.

Many women prefer acetyl hexapeptide-8 because it is more natural than Botox®. And there are no injections. And no pain. Not to mention the cost and potential side effects. In addition, some research suggests that amino acids can help to smooth the look of the skin.

As a result, you will see a reduction in the appearance of wrinkles but also an improvement in skin tone brightness.

Red Carpet Ready

Hollywood's best-kept secret is how many of them use Botox® and other fillers to look red carpet ready. So, what do you do if you are not prepared to start using Botox® and different types of injections but don't want to look like a prune?

Argireline can help. A 10% concentration with 10% Snap 8 and 5% Syn-Ake can act as the best frown line smoother. Plus, reduce the appearance of crow's feet. These three peptides work together to smooth vertical wrinkles and crow's feet, the ones that make you look like you are squinting when you are not.

Best of all, it can prolong the effects of Botox®. This concoction of peptides is your best defense against the signs of aging.

Did you know that most men and women who use Botox® get injected every three months? Botox® is said to last for up to 6 months. However, the best results from Botox® are in the first and second months of use. After the second month, the effects taper off dramatically.

The fantastic results you once saw vanish, leaving you feeling like those frown lines are coming back. The effects that disappear will make you want to make another trip to the dermatologist for another treatment.

Enhance Results with Topicals

Many men and women get Botox® every 2 1/2 to 3 months because the results don't last. Here is your chance to prolong the effects of Botox®! You can make the results last longer with a topical treatment — no more expensive trips to the dermatologist.

Or, if you're like most of us, experience smoother frown lines without using painful injections!

Remember, peptides are a safe, effective alternative to injections if you are looking for more natural anti-aging ingredients. Likewise, our highly concentrated serums are a great way to look younger! Plus, they are worth the look at less than half of one Botox® treatment cost.

Argireline Solution 10%

At Skin Perfection, we recommend using the Argireline peptide solution c in a concentration of 10%. The manufacturer recommends using a 3 - 10% concentration. Make sure that you purchase Solution C in the non-paraben version. Many drugstore and department store products contain 3%.

Multiple studies have shown that using a 10% solution can significantly reduce the appearance of wrinkles. In addition, you can quickly make a DIY homemade Argireline serum vs. a botox injection with our peptide serum boosters at home in under 5 minutes! Plus, you know every single ingredient that is in your product.

There is no more natural way to get a chemical-free, gluten-free, filler-free, and paraben-free serum for under $8! Yep. The entire concoction will cost less than $8 to make.

Here's how: Add one teaspoon of Argireline Serum Booster to 5 teaspoons of water. Pour into a 30 ml bottle and shake. For long-term storage, consider adding a preservative. Use morning and night under a moisturizer to smooth out wrinkles.

Boost your Serum with Powerful Peptides

We recommend using Argireline with other peptides to obtain the best results.

  • For fine lines and wrinkles or crow's feet, use Snap 8 Peptide, Inyline Peptide, or Leuphasyl. For an herbal extract, use Okra or Gotu Kola.
  • If you have a loss of firmness and wrinkles, use Syn-Ake, Pepha Tight, Relistase Peptide, and Uplevity. For a natural botanical, incorporate bamboo, wheat protein, and pea extract.
  • For dark under-eye circles, use Haloxyl. Use okra, cucumber, caffeine, or tea extracts as a natural ingredient.

Consistency is critical for the best results of using peptides in your skincare. Regular facials, weekly exfoliation treatments, and hydrating from within can enhance your skin's glow and reduce the appearance of wrinkles.

How to Reverse Engineer The Ordinary Argireline Solution 10%

Here are the ingredients used in the Argireline Solution 10%

  • Aqua-Water. For dilution, an added filler, water doesn't do anything for your skin.
  • Propanediol - Glycol derived from corn.
  • Acetyl Hexapeptide-8 - Argireline in a 10% concentration.
  • Trisodium Ethylenediamine Disuccinate - naturally derived chelating agent.
  • Gellan Gum - Thickener.
  • Sodium Chloride - Salt is usually used to adjust the PH.
  • Isoceteth-20 - Polyethylene Glycol Solvent.
  • Dimethyl Isosorbide - Solvent.
  • Potassium Sorbate - Preservative.
  • Phenoxyethanol - Preservative.
  • Chlorphenesin - Synthetic Preservative.

To make a clean beauty product with a 10% Argireline Solution without all the chemicals, fillers, or synthetic preservatives, we will take out all the nasties!
We can replace the water with beneficial Hyaluronic Acid.

Our version of the Pure Solution with 10% Argireline More peptides with no fillers equals better skin care products!
30 ml Hyaluronic Acid
.3 ml Argireline

Reviews of Argireline® Peptide

Great booster! I quickly mixed in my serum! The seller was so helpful! I asked her at least a dozen questions, and she was so lovely. It also arrived in two days! Thank you!

Making my own products is a must. I couldn't do without it. Fantastic website and is easy to order. And fast shipping.

Mixes well with other products; too soon to see results. Thank you.

I appreciated the opportunity to mix this into my existing favorite moisturizer! Excellent instructions, etc., blown away by the fast shipping and careful packaging! Saw immediate results from the first use! Thanks! I'll be back!

This stuff is excellent. My face looks much fresher, and the wrinkles seem reduced. I would order it again at any time.

I quickly add a 10% concentration of Argireline to my DIY serum, and I love it!

This is assessing its effectiveness. I will provide an update.

Fast delivery!

More Raving Reviews!

I can't wait to add this to my moisturizer and start reducing wrinkles. :) Thanks

It is just amazing; the lines around my eyes are so less noticeable!

Mixes easily with other lotions; skin feels smooth.

I love this product and use it all the time, and it works.

Feels good on your face. It does smooth outlines and works very well. Moisturizers go on well after using this product.

I will always order.

Love it!

Best peptide.

It is a wonderful, amazing magical anti-aging to mix in your other serums like Hyaluronic Acid or Vitamin C, and do not apply directly to the face. It tells you right on instructions and gives you how many drops to put into your serums to provide that extra boost. But first, be sure your serums don't have them already in them. It's expensive, but great stuff. I also like playing scientist and making my Vitamin C concoctions. At times to go organic natural, no more store brand names. But I've thrown out enough money on junk filled with perfumes. Yuk!

I immediately saw a huge difference and continued to do so even after a year. I really, really like this product.

If you are considering making a homemade serum, try the formulas below.

Recipes with Argireline

Gel Serum
1 Ounce Hyaluronic Acid-Base
1 Teaspoon Argireline

Argireline Wrinkle Cream
1 Ounce Rejuvenating Serum Base
1 Teaspoon Argireline
2-3 Drops of Plant Therapy Anti-Age Essential Oil

Anti-Aging Eye Cream
1 Ounce Regenerating Facial Cream Lotion Base
1 Teaspoon Argireline
1 Ounce Rose Hydrosol
1 Drop Plant Therapy Frankincense


About the Author
This article has been reviewed by Dr. Jen Haley, a board-certified dermatologist.

References are made to third-party trademarks. ARGIRELINE™ is a trademark of Lipotec S.A. or affiliates. Skin Perfection is not affiliated with these trademarks or their owners.