Your Shopping Cart Cart is empty


The number 1 wrinkle remedy

Argireline is the Most Trusted Anti-Aging Peptide Today

EWG Rating
Argireline, The Most Trusted Anti-Aging Peptide Today

Scientific Name: {Acetyl Hexapeptide-8}
Common Name: {Argireline, Natural Botox® Alternative}

Argireline, the most trusted anti-aging peptide. It is one of the most widely used and reputable anti-wrinkle ingredients in the skincare industry today. It is made up of a strand of amino acids. The amino acids help the expression line muscles, that we use daily, relax.

The SNARE Complex accomplishes this. When our facial muscles are relaxed, they don't contract as often. Promoting a reduction in the appearance of wrinkles.

Botox® paralyzes the muscle, so it is unable to contract. Acetyl Hexapeptide-8 is one of the best alternatives to wrinkle injections. It targets the most used expression lines, such as crow's feet and brow furrows.

So if you are looking to stay away from needles, this is one anti-aging peptide to check out! It is recommended to use a 10% concentration morning and night.

What is Argireline?

It is an anti-aging peptide. A peptide is a protein which is the building blocks of our skin.

Snare Complex to Relax Wrinkles What is a peptide? It is a strand of amino acids. The type of peptide depends on the beginning; for example, a tripeptide is a strand of three amino acids. Hexa means 6, Penta means 5, etc..

At one time, it was called Acetyl Hexapeptide-3. However, it is now referred to as Acetyl Hexapeptide-8. So if you see it referenced with a 3, then the article or label is more than likely old and not updated. 

Women widely use it as an alternative to Botox®. As it is often referred to as "botox in a bottle." Unlike Botox®, however, it does not require expensive injections and has far fewer and less extreme side effects.

Specifically, a hexapeptide, which means it has six amino acids linked together. Amino acids are proteins, and they are essential for all life.

Its scientific name is Acetyl Hexapeptide-8. When it first came onto the market, it was called Acetyl Hexapeptide-3. This has caused some confusion in the marketplace. If you see a product using "Acetyl Hexapeptide-3" it is usually due to the fact that they have not updated labels or website information. It is used as a replacement for more extreme anti-aging measures because it is designed to perform the same functions.

When applied topically, it works against the Neurotransmitter. Neurotransmitters signal muscles in specific areas, relaxing the muscle. Then, in turn, relaxing the appearance of wrinkles above that muscle.

In the face, we have several muscles that we use daily to express certain emotions. We may be contracting them without even noticing it. When you squint repeatedly, crow's feet begin to appear around the eyes. When squinting is stopped, these tiny little wrinkles disappear. Over time, as we age, these muscles become permanently contracted, and the lines above them also become permanent.
neurotransmitters synapse for skin-smoothing properties
These are most commonly called “expression lines,” and occur around the eyes, around the mouth, and on the forehead, our most “active” facial areas. These lines may start small, but as time goes on, become thick and pronounced.

Argireline penetrates the skin and, just like Botox®, partially paralyzes the muscles beneath the skin, so that they cannot contract. On the surface of the skin, we see the look of these lines and wrinkles become relaxed.

To tackle multiple signs of aging, combined with a peptide that lifts and firms or boosts collagen. Argireline can be handy at diminishing the appearance of these lines and wrinkles, which are often the most telling signs of age. But it can work even better when used with other ingredients.

Studies have shown that women using a 10% solution throughout a month, saw up to 30% reduction in the depth of their most problematic wrinkles. That can remove years and years of aging from your face!

The study is why you have seen and heard Dr. Oz raving about Argireline on his TV show. Dr. Oz shares that there are significant anti-aging products available. They don't have to cost a fortune or loaded with a million chemicals. With clinical studies to back up, its claims, Argireline is one of the best tried and true anti-aging ingredients among women today.

It works on the forehead, laugh lines, and furrows. And it is excellent for crow's feet around the eyes, quickly take years off your appearance. It's just an all-around great ingredient.

Acetyl Hexapeptide-8 or Argireline Side Effects

There is a lot of hype on the internet. One primary concern is if there are any side effects of using Argireline. Some men and women have read that Argireline will cause sagging skin and make their faces sag.

Others are concerned about the fact that it inhibits muscle contraction. When face muscles are tight and rigid, they can cause the face to wrinkle up. Think about the eyebrow furrows; they are one or two muscles that are scrunched up and tight.

Squinting can create fine lines, creases, wrinkles, and ridges. Or think about the crow's feet around the eyes. When you are in the sun, your eyes squint. The more you squint, the sooner you will begin to see crow's feet around the eyes. When your face muscles are relaxed, your face is smoother and less wrinkled.

Argireline is as safe as any other anti-aging product. It is much safer to use that Botox®, which can easily cause toxicity in the face and has some undesirable side effects. Such as droopy eyelids.

Many women prefer to use acetyl hexapeptide-8 because it is more natural than Botox®. And there are no injections. And no pain. Not to mention the cost and potential side effects. Some research suggests that the amino acids can help to smooth the look of skin. You will see a reduction in the appearance of wrinkles but also an improvement in skin-tone brightness.

Red Carpet Ready

Hollywood's best-kept secret is how many of them use Botox® and other fillers to look red carpet ready. If you are not prepared to start using Botox® and different types of injections but don't want to look like a prune either, what do you do?

Argireline can help. Using a 10% concentration with 10% Snap 8 and 5% Syn-Ake, it can act as the best frown line smoother. Plus, reduce the appearance of crow's feet. These three peptides work together to smooth vertical wrinkles and crow's feet, the ones that make you look like your squinting when your not.

Best of all, it can prolong the effects of Botox®. This concoction of peptides is your best defense against the signs of aging.

Did you know that most men and women who use Botox® get injected every three months? Botox® is said to last for up to 6 months. However, the best results from Botox® are in the first and second month of use. After the second month, effects taper off dramatically.

The fantastic results you once saw vanish, leaving you feeling like those frown lines are coming back. The results that disappear will make you want to make another trip to the dermatologist for another treatment.

Many men and women get Botox® every 2 1/2 to 3 months because the results don't last. Here is your chance to prolong the effects of Botox®! With a topical treatment, you can make the results last longer — no more expensive trips to the dermatologist. Or if you're like most of us, experience the effects of smoother frown lines without using painful injections!

Remember, if you are looking for more natural anti-aging ingredients, peptides are a safe, effective alternative to injections. Our highly concentrated serums are a great way to look younger! Plus, at less than half of the cost of one Botox® treatment, they are worth the look.

Argireline Solution 10%

At Skin Perfection, we recommend using the Argireline peptide solution c in a concentration of 10%. The manufacturer recommends using a 3 - 10% concentration. Solution c is the non-paraben version. Many drugstore and department store products contain 3%.

Multiple studies have shown that using a 10% solution can significantly reduce the appearance of wrinkles. You can quickly make a DIY homemade Argireline serum to vs a botox injection with our peptide serum boosters at home in under 5 minutes! Plus, you know every single ingredient that is in your product.

There is no more natural way to get a chemical-free, gluten-free, filler-free, and paraben-free serum for under $8! Yep. The entire concoction will cost less than $8 to make.

Here's how: Add one teaspoon Argireline Serum Booster to 5 teaspoons water. Pour into a 30 ml bottle and shake. For long-term storage, consider adding a preservative. Use morning and night under a moisturizer to smooth out wrinkles.

We recommend using Argireline with other peptides to obtain the best results.

  • For fine lines and wrinkles or crow's feet, use with Snap 8, Inyline or Leuphasyl. For an herbal extract, use with Okra or Gotu Kola.
  • For loss of firmness along with wrinkles, use with Syn-Ake, Pepha Tight, Relistase, and Uplevity. For a natural botanical incorporate with bamboo, wheat protein, and pea extract.
  • For under-eye circles use with Haloxyl. For a natural ingredient, use okra, cucumber, caffeine, or tea extracts.

For the best results of using peptides in your skincare, consistency is key. Regular facials, weekly exfoliations treatments, hydrating from within can all contribute to enhancing your skin's glow and reducing the appearance of wrinkles.

How to Replicate The Ordinary Argireline Solution 10%

Here are the ingredients used in the Argireline Solution 10%

Aqua - Water, for dilution, added filler, water that doesn't do anything for your skin
Propanediol - Glycol derived from corn
Acetyl Hexapeptide-8 - Argireline in a 10% concentration 
Trisodium Ethylenediamine Disuccinate - naturally derived chelating agent
Gellan Gum - Thickener
Sodium Chloride - Salt usually used to adjust the PH
Isoceteth-20 - Polyethylene Glycol Solvent
Dimethyl Isosorbide - Solvent
Potassium Sorbate - Preservative
Phenoxyethanol - Preservative
Chlorphenesin - Synthetic Preservative

To make a clean beauty 10% Argireline Solution without all the chemicals, fillers, or synthetic preservatives, we are going to take out all the nasties!
We can replace the water with beneficial Hyaluronic Acid.

Here is our version of the Pure Solution with 10% Argireline More peptides with no fillers equals better products!
30 ml Hyaluronic Acid
.3 ml Argireline

Product Reviews

Great booster! I easily mixed in my serum! The seller was so helpful! I asked her at least a dozen questions, and she was so lovely. It also arrived in two days! Thank you!

Making my own products, and this is a must. Couldn't do without it. Fantastic website and easy to order. And fast shipping.

Mixes well with other products, too soon to see results. Thank you.

I appreciated the opportunity to mix this into my existing favorite moisturizer! Excellent instructions, etc., blown away by the fast shipping, careful packaging! Saw immediate results from the first use! Thanks! I'll be back!

This stuff is great. My face looks much fresher, and the wrinkles seem reduced. I would order it again at any time.

I quickly add a 10% concentration of Argireline to my DIY serum, and I love it!

This is assessing its effectiveness. I will provide an update.

Fast delivery! I can't wait to add this to my moisturizer and start reducing wrinkles. :) Thanks

I really love this; I saw results immediately!

It is just amazing; my lines around my eyes are so less noticeable!

Mixes easily with other lotions skin feels smooth.

Love this product use it all the time, and it works.

Feels good on your face. It does smooth outlines and works very well. Moisturizers go on well after using this product.

Will always order.

Love it!

Best peptide.

Wonderful, amazing magical anti-aging to mix in your other serums like Hyaluronic Acid or Vitamin C, and do not apply directly to the face. It tells you right on instructions. It also gives you how many drops to put into your serums to provide that extra boost. But first, be sure your serums don't have it already in it. Expensive, but great stuff. I also like playing scientist making my Vitamin C concoctions. At times to go organic natural no more store brand names. But I've thrown out enough money on junk filled with perfumes. Yuk!

I immediately saw a huge difference and continue to do so even after a year I really, really like this product.

If you are considering making a homemade serum.


Gel Serum
1 Ounce Hyaluronic Acid-Base
1 Teaspoon Argireline

Argireline Wrinkle Cream
1 Ounce Rejuvenating Serum Base
1 Teaspoon Argireline
2-3 Drops Plant Therapy Anti-Age Essential Oil

Anti-Aging Eye Cream
1 Ounce Regenerating Facial Cream Lotion Base
1 Teaspoon Argireline
1 Ounce Rose Hydrosol
1 Drop Plant Therapy Frankincense


2 item(s) - Page 1 of 1

About Skin Perfection

We’re here to help you create clean beauty products and get you looking younger. We’ve put together our best tips for making your own skincare products, finding the best anti-aging ingredients plus in-depth videos and guides.

Learn more about our team here.

Getting Started and Guides

Make sure to start with the right setup. Learn how to create your DIY skincare the right way. It'll make your life so much easier. Here's how:

The Best Peptides

We've used all of the best peptides out there. Some of them we love. Others we didn't. Learn from our experience on which anti-aging peptides work.

Best-Selling Skincare

Need a ready-made solution? Check out our best selling anti-aging products including serums and moisturizers. We've got you.